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pi 3-Kinase p85 (pTyr467), (pTyr199), (pTyr464) antibody

Details for Product No. ABIN401567
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Antigen
Epitope
pTyr467, pTyr199, pTyr464
(3), (2), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(5), (4), (3), (3), (1)
Host
Rabbit
(4), (3)
Clonality
Polyclonal
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(5), (4), (2), (2), (2), (1), (1), (1)
Pubmed 3 references available
Quantity 50 µg
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Catalog No. ABIN401567
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Immunogen The antiserum was produced against synthesized non-phosphopeptide derived from human PI3K P85 alpha/gamma/beta around the phosphorylation site of Tyrosine 467/199/464 (L-Yp-E-E-Y).
Specificity This antibody detects endogenous levels of total PI3K P85 alpha/gamma/beta protein.
Purification Immunoaffinity Chromatography using epitope-specific immunogen.
Background The enzyme phosphatidylinositol 3 kinase (PI3 kinase) is a lipid kinase that generates phosphatidylinositol 3, 4, 5-triphosphate in response to receptor activation in many signal transduction pathways. Class IA PI3Ks exist as a heterodimer of a catalytic 110 kDa (p110) and a regulatory p85 subunit (e.g. p85 alpha). p85 alpha is an adaptor molecule that regulates the activity of the catalytic p110 subunit by binding to phosphorylated receptor tyrosine kinases (RTKs) through its SH2 domain and mediating the interaction between p110 and the plasma membrane. p85 alpha is necessary for insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues.
Alternate names: GRB1, PIK3R1, PIK3R2, PIK3R3, Phosphatidylinositol 3-kinase regulatory subunit alpha, beta, gamma
Gene ID 5295
NCBI Accession NP_852556
UniProt P27986
Application Notes Immunohistochemistry on Paraffin Sections: 1/50~1/100. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02% Sodium Azide and 50% Glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at-20°C.
Expiry Date 12 months
Supplier Images
anti-pi 3-Kinase p85 (pTyr467), (pTyr199), (pTyr464) antibody anti-pi 3-Kinase p85 (pTyr467), (pTyr199), (pTyr464) antibody
Background publications Stoyanov, Volinia, Hanck et al.: "Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase." in: Science (New York, N.Y.), Vol. 269, Issue 5224, pp. 690-3, 1995 (PubMed).

Simpson, Parsons: "PTEN: life as a tumor suppressor." in: Experimental cell research, Vol. 264, Issue 1, pp. 29-41, 2001 (PubMed).

Neri, Borgatti, Capitani et al.: "The nuclear phosphoinositide 3-kinase/AKT pathway: a new second messenger system." in: Biochimica et biophysica acta, Vol. 1584, Issue 2-3, pp. 73-80, 2002 (PubMed).

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