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GRIN2B antibody (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B) (pTyr1474)

Details for Product anti-GRIN2B Antibody No. ABIN401599, Supplier: Log in to see
Antigen
  • AW490526
  • GluN2B
  • hNR3
  • MRD6
  • Nmdar2b
  • nmdar2b
  • NMDAR2B
  • NR2B
  • nr2b
Epitope
pTyr1474
52
47
39
38
32
27
17
16
14
14
14
13
13
13
12
4
4
4
3
3
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
297
295
237
15
9
8
5
4
4
4
3
2
2
1
1
Host
Rabbit
297
59
14
Clonality
Polyclonal
Conjugate
This GRIN2B antibody is un-conjugated
12
12
10
9
9
9
9
9
9
9
9
9
5
3
3
2
2
2
2
2
2
2
2
2
2
2
1
1
Application
Immunofluorescence (IF)
249
99
90
75
75
56
46
17
10
4
3
2
2
1
1
Supplier
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Immunogen Synthesized phosphopeptide derived from human NMDAR2B around the phosphorylation site of Tyr1474 (H-V-YP-E-K)
Specificity NMDAR2B (phospho-Tyr1474) antibody detects endogenous levels of NMDAR2B only when phosphorylated at Tyr1474.
Purification Affinity-chromatography
Alternative Name NMDAR2B (GRIN2B Antibody Abstract)
Background NMDA receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long term potentiation, an activity dependent increase in the efficiency of synaptic transmission thought to underlie certain types of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). GRIN2B may be a candidate gene for the neurodegenerative disorder dentato-rubro-pallidoluysian atrophy (DRPLA). Properties of NMDAR include modulation by glycine, inhibition by Zn2+, voltage dependent Mg2+ blockade and high Ca2+ permeability. The involvement of NMDAR in the CNS has become a focus area for neurodegenerative diseases such as Alzheimer's disease, epilepsy and ischemic neuronal cell death.Synonyms: GRIN2B, Glutamate [NMDA] receptor subunit epsilon-2, N-methyl D-aspartate receptor subtype 2B, N-methyl-D-aspartate receptor subunit 3, NMDA Receptor 2B
Gene ID 2904
NCBI Accession NP_000825
UniProt Q13224
Research Area Neurology, Neurotransmitters, Receptors
Application Notes Immunofluorescence: 1/100 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1,0 mg/mL
Buffer Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Supplier Images
 image for anti-GRIN2B antibody (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B) (pTyr1474) (ABIN401599) anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B) (pTyr1474) antibody
Background publications Liu, Murray, Jones: "Switching of NMDA receptor 2A and 2B subunits at thalamic and cortical synapses during early postnatal development." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 24, Issue 40, pp. 8885-95, 2004 (PubMed).

Westphal, Tavalin, Lin, Alto, Fraser, Langeberg, Sheng, Scott: "Regulation of NMDA receptors by an associated phosphatase-kinase signaling complex." in: Science (New York, N.Y.), Vol. 285, Issue 5424, pp. 93-6, 1999 (PubMed).

Tingley, Ehlers, Kameyama, Doherty, Ptak, Riley, Huganir: "Characterization of protein kinase A and protein kinase C phosphorylation of the N-methyl-D-aspartate receptor NR1 subunit using phosphorylation site-specific antibodies." in: The Journal of biological chemistry, Vol. 272, Issue 8, pp. 5157-66, 1997 (PubMed).

Krueger, Daaka, Pitcher, Lefkowitz: "The role of sequestration in G protein-coupled receptor resensitization. Regulation of beta2-adrenergic receptor dephosphorylation by vesicular acidification." in: The Journal of biological chemistry, Vol. 272, Issue 1, pp. 5-8, 1997 (PubMed).