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Details for Product No. ABIN401642

Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) (Ser2481) antibody

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Antigen
Synonyms FRAP, FRAP1, FRAP2, RAFT1, RAPT1, 2610315D21Rik, AI327068, Frap1, flat, frap1, tor, wu:fc22h08
Epitope
»Alternatives Ser2481
Reactivity
»Alternatives Human, Mouse (Murine), Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Pubmed 4 references available
Catalog no. ABIN401642
Quantity 0.1 mg
Price
297.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen Synthesized non-phosphopeptide derived from human mTOR around the phosphorylation site of serine 2481 (I-H-SP-F-I).
Specificity MTOR Antibody detects endogenous levels of total mTOR protein.
Purification Affinity chromatography
Alternative Name mTOR / FRAP1
Background MTOR, or FKBP12 rapamycin associated protein (FRAP), is one of a family of proteins involved in cell cycle progression, DNA recombination, and DNA damage detection. In rat, it is a 289-kDa protein (symbolized RAFT1) with significant homology to the Saccharomyces cerevisiae protein TOR1 and has been shown to associate with the immunophilin FKBP12 in a rapamycin dependent fashion. The FKBP12-rapamycin complex is known to inhibit progression through the G1 cell cycle stage by interfering with mitogenic signaling pathways involved in G1 progression in several cell types, as well as in yeast. The binding of FRAP to FKBP12-rapamycin correlated with the ability of these ligands to inhibit cell cycle progression.
Alternate names: FK506-binding protein 12-rapamycin complex-associated protein 1, FKBP12-rapamycin complex-associated protein, FRAP, FRAP2, Mammalian target of rapamycin, RAPT1, Rapamycin target protein, Serine/threonine-protein kinase mTOR, TOR
Gene ID 2475
NCBI Accession NP_004949
UniProt P42345
Application Notes Immunohistochemistry: 1/50 - 1/100. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1,0 mg/mL
Buffer Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Expiry Date 12 months
Background publications Stull, Hyun, Sharetzsky et al.: "Production and oxidation of indole by Haemophilus influenzae." in: The Journal of biological chemistry, Vol. 270, Issue 1, pp. 5-8, 1995 (PubMed).

Brown, Albers, Shin et al.: "A mammalian protein targeted by G1-arresting rapamycin-receptor complex." in: Nature, Vol. 369, Issue 6483, pp. 756-8, 1994 (PubMed).

Carraway, Cantley: "A neu acquaintance for erbB3 and erbB4: a role for receptor heterodimerization in growth signaling." in: Cell, Vol. 78, Issue 1, pp. 5-8, 1994 (PubMed).

Dennis, Jaeschke, Saitoh et al.: "Mammalian TOR: a homeostatic ATP sensor." in: Science (New York, N.Y.), Vol. 294, Issue 5544, pp. 1102-5, 2001 (PubMed).

Alternatives for antigen "Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1)", type "Antibodies"
Hosts (240), (13), (1), (1)
Reactivities (243), (152), (146), (63), (36), (24), (5), (2), (1)
Applications (139), (86), (75), (54), (50), (35), (24), (22), (3), (3), (3), (2), (2), (1)
Conjugates (6), (6), (5), (5), (5), (5), (5), (5), (5), (5), (5), (2)
Epitopes (43), (19), (18), (12), (8), (7), (6), (5), (4), (4), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
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