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KIT antibody (Mast/stem Cell Growth Factor Receptor) (AA 934-938)

Details for Product anti-KIT Antibody No. ABIN401646, Supplier: Log in to see
Antigen
  • Bs
  • CD117
  • Fdc
  • Gsfsco1
  • Gsfsco5
  • Gsfsow3
  • SCO1
  • SCO5
  • SOW3
  • Ssm
  • Tr-kit
  • W
  • c-KIT
  • C-Kit
  • PBT
  • SCFR
  • MGF
  • c-kit
  • kit oncogene
  • v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
  • Kit
  • KIT
Alternatives
anti-Human KIT antibody for Immunofluorescence
Epitope
AA 934-938
54
43
39
31
27
25
25
17
16
15
15
15
15
14
13
11
10
10
10
10
10
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9
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9
9
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7
7
7
7
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5
5
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4
3
3
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
910
460
158
40
35
31
21
19
14
6
6
5
4
3
2
1
1
Host
Rabbit
677
290
213
4
2
1
Clonality
Polyclonal
Conjugate
This KIT antibody is un-conjugated
106
91
84
64
49
39
20
16
14
10
10
10
9
8
8
8
8
8
8
7
5
5
5
5
5
4
4
4
4
3
3
3
3
2
2
2
2
2
2
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
414
402
398
187
179
150
105
96
76
61
28
13
13
11
10
8
4
4
3
3
2
2
2
2
2
2
2
Options
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Immunogen peptide sequence around amino acids 934~938 (H-I-Y-S-N) derived from Human c-kit.
Specificity C-kit Antibody detects endogenous levels of total c-kit protein.
Purification Affinity Chromatography using epitope-specific peptide
Alternative Name CD117 / C-Kit (KIT Antibody Abstract)
Background C-Kit is a transmembrane tyrosine kinase encoded by the cKit proto oncogene. c-Kit acts to regulate a variety of biological responses including cell proliferation, apoptosis, chemotaxis and adhesion. Ligand binding to the extracellular domain leads to autophosphorylation on several tyrosine residues within the cytoplasmic domain, and activation. Mutations in c-Kit have been found to be important for tumor growth and progression in a variety of cancers including mast cell diseases, gastrointestinal stromal tumor, acute myeloid leukemia, Ewing sarcoma and lung cancer. Phosphorylation at tyrosine 721 of c-Kit allows binding and activation of PI3 kinase.Synonyms: KIT, Mast/stem cell growth factor receptor, Proto-Oncogene Tyrosine-Protein Kinase, SCFR
Gene ID 3815
NCBI Accession NP_000213
UniProt P10721
Research Area CD Antigens, Surface Receptors of Immune Cells, Growth Factors, Receptors, Proliferation Markers
Pathways RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Sensory Perception of Sound, Stem Cell Maintenance, Production of Molecular Mediator of Immune Response
Application Notes Immunohistochemistry: 1/50 - 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Supplier Images
 image for anti-KIT antibody (Mast/stem Cell Growth Factor Receptor) (AA 934-938) (ABIN401646) anti-Mast/stem Cell Growth Factor Receptor (KIT) (AA 934-938) antibody
Background publications Blume-Jensen, Jiang, Hyman, Lee, OGorman, Hunter: "Kit/stem cell factor receptor-induced activation of phosphatidylinositol 3'-kinase is essential for male fertility." in: Nature genetics, Vol. 24, Issue 2, pp. 157-62, 2000 (PubMed).

Lowe: "Colipase stabilizes the lid domain of pancreatic triglyceride lipase." in: The Journal of biological chemistry, Vol. 272, Issue 1, pp. 9-12, 1997 (PubMed).

Martin, Suggs, Langley, Lu, Ting, Okino, Morris, McNiece, Jacobsen, Mendiaz: "Primary structure and functional expression of rat and human stem cell factor DNAs." in: Cell, Vol. 63, Issue 1, pp. 203-11, 1990 (PubMed).

Nocka, Tan, Chiu, Chu, Ray, Traktman, Besmer: "Molecular bases of dominant negative and loss of function mutations at the murine c-kit/white spotting locus: W37, Wv, W41 and W." in: The EMBO journal, Vol. 9, Issue 6, pp. 1805-13, 1990 (PubMed).