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TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 1 (TAB1) (Ser438) antibody

Details for Product No. ABIN401658
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Antigen
Synonyms MAP3K7IP1, 3'-Tab1, 2310012M03Rik, Map3k7ip1, b2b449Clo
Epitope
Ser438
(16), (12), (11), (10), (7), (5), (4), (4), (3), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(109), (56), (48), (38), (37), (37), (13), (1), (1)
Host
Rabbit
(97), (13), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(6), (6), (6), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3)
Application
ELISA, Western Blotting (WB)
(71), (48), (30), (14), (12), (11), (8), (5), (2), (1), (1), (1), (1)
Pubmed 2 references available
Quantity 0.4 mL
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
Catalog No. ABIN401658
346.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the amino acid residues surrounding Ser438 of human MAP3K7IP1.
Specificity Antibody recognizes MAP3K7IP1 pSer438.
Purification Protein A Chromatography followed by peptide Affinity purification.
Alternative Name TAB1 / MAP3K7IP1
Background MAP3K7IP1 was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli.
Alternate names: Mitogen-activated protein kinase kinase kinase 7-interacting protein 1, TAK1-binding protein 1, TGF-beta-activated kinase 1-binding protein 1
Molecular Weight 54644 Da
Gene ID 10454
NCBI Accession NP_006107
UniProt Q15750
Application Notes ELISA: 1/1,000Western blot: 1/100~500. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09% (w/v) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at-20°C for longer.
Expiry Date 12 months
Supplier Images
anti-TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 1 (TAB1) (Ser438) antibody anti-TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 1 (TAB1) (Ser438) antibody
Background publications Arch, Gedrich, Thompson: "Tumor necrosis factor receptor-associated factors (TRAFs)--a family of adapter proteins that regulates life and death." in: Genes & development, Vol. 12, Issue 18, pp. 2821-30, 1998 (PubMed).

Yamaguchi, Nagai, Ninomiya-Tsuji et al.: "XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway." in: The EMBO journal, Vol. 18, Issue 1, pp. 179-87, 1999 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN401658
346.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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