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TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 1 (TAB1) (Ser438) antibody

Details for Product No. ABIN401658, Supplier: Log in to see
Antigen
  • 3'-Tab1
  • MAP3K7IP1
  • 2310012M03Rik
  • Map3k7ip1
  • b2b449Clo
Alternatives
anti-Human TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 1 antibody for Western Blotting
Epitope
Ser438
25
18
15
15
13
8
6
5
5
4
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
168
68
59
2
1
1
1
1
Host
Rabbit
149
17
2
Clonality
Polyclonal
Conjugate
Un-conjugated
10
10
9
6
6
6
4
3
3
3
3
3
3
3
3
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
108
69
34
18
14
10
10
9
6
4
2
1
1
Supplier
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Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the amino acid residues surrounding Ser438 of human MAP3K7IP1.
Specificity AP09519PU-N recognizes MAP3K7IP1 pSer438.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Protein A Chromatography followed by peptide Affinity purification.
Alternative Name TAB1 / MAP3K7IP1 (TAB1 Antibody Abstract)
Background MAP3K7IP1 was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli.Synonyms: Mitogen-activated protein kinase kinase kinase 7-interacting protein 1, TAK1-binding protein 1, TGF-beta-activated kinase 1-binding protein 1
Molecular Weight 54644 Da
Gene ID 10454
NCBI Accession NP_006107
UniProt Q15750
Pathways TLR Signaling, Fc-epsilon Receptor Signaling Pathway
Application Notes ELISA: 1/1,000Western blot: 1/100approx. 500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Supplier Images
 image for anti-TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 1 (TAB1) (Ser438) antibody (ABIN401658) anti-TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 1 (TAB1) (Ser438) antibody
Background publications Yamaguchi, Nagai, Ninomiya-Tsuji et al.: "XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway." in: The EMBO journal, Vol. 18, Issue 1, pp. 179-87, 1999 (PubMed).

Arch, Gedrich, Thompson: "Tumor necrosis factor receptor-associated factors (TRAFs)--a family of adapter proteins that regulates life and death." in: Genes & development, Vol. 12, Issue 18, pp. 2821-30, 1998 (PubMed).