Tripartite Motif Containing 23 (TRIM23) (N-Term) antibody

Details for Product No. ABIN404775
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Antigen
Synonyms zgc:153463, ARD1, ARFD1, RNF46, 6330516O20Rik, AI450195, Arfd1, Ard1
Epitope
N-Term
(9), (8), (7), (3), (2), (2), (2), (2), (1), (1), (1)
Reactivity
Mouse (Murine), Human
(36), (4), (4), (2), (2), (2), (2)
Host
Rabbit
(23), (13), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB)
(35), (20), (9), (3), (2), (2), (2)
Pubmed 1 reference available
Quantity 50 µg
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Catalog No. ABIN404775
289.00 $
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Immunogen Synthetic peptide directed towards the N terminal of human TRIM23
Sequence CPFDRQVTDL GDSGVWGLKK NFALLELLER LQNGPIGQYG AAEESIGISG
Predicted Reactivity Human : 100 %, Guinea pig : 80 %, Horse : 80 %, Pig : 80 %, Rabbit : 80 %
Characteristics This is a rabbit polyclonal antibody against TRIM23. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name TRIM23
Background TRIM23 is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein is also a member of the ADP ribosylation factor family of guanine nucleotide-binding family of proteins. Its carboxy terminus contains an ADP-ribosylation factor domain and a guanine nucleotide binding site, while the amino terminus contains a GTPase activating protein domain which acts on the guanine nucleotide binding site. The protein localizes to lysosomes and the Golgi apparatus. It plays a role in the formation of intracellular transport vesicles, their movement from one compartment to another, and phopholipase D activation. Three alternatively spliced transcript variants for this gene have been described. The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein is also a member of the ADP ribosylation factor family of guanine nucleotide-binding family of proteins. Its carboxy terminus contains an ADP-ribosylation factor domain and a guanine nucleotide binding site, while the amino terminus contains a GTPase activating protein domain which acts on the guanine nucleotide binding site. The protein localizes to lysosomes and the Golgi apparatus. It plays a role in the formation of intracellular transport vesicles, their movement from one compartment to another, and phopholipase D activation. Three alternatively spliced transcript variants for this gene have been described.
Molecular Weight 64 kDa
Gene ID 373
NCBI Accession NM_001656, NP_001647
UniProt P36406
Research Area Signaling
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 574 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Tripartite Motif Containing 23 (TRIM23) (N-Term) antibody WB Suggested Anti-TRIM23 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: 293T cell lysate
Background publications Vichi, Payne, Pacheco-Rodriguez et al.: "E3 ubiquitin ligase activity of the trifunctional ARD1 (ADP-ribosylation factor domain protein 1)." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 6, pp. 1945-50, 2005 (PubMed).

Validation Images
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