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Tripartite Motif Containing 23 (TRIM23) (N-Term) antibody

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Antigen
Synonyms zgc:153463, ARD1, ARFD1, RNF46, 6330516O20Rik, AI450195, Arfd1, Ard1
Epitope
N-Term
(21), (15), (4), (4), (4), (3), (2), (2), (2), (2), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(55), (14), (9), (5), (4), (4), (2), (2)
Host
Rabbit
(44), (10), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB)
(51), (30), (17), (5), (4), (2), (1), (1), (1), (1), (1)
Pubmed 1 reference available
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Quantity 50 μg
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Immunogen Synthetic peptide directed towards the N terminal of human TRIM23
Blocking Peptide Blocking peptide for this product available: ABIN985497
Sequence CPFDRQVTDL GDSGVWGLKK NFALLELLER LQNGPIGQYG AAEESIGISG
Predicted Reactivity Human : 100 %, Guinea pig : 80 %, Horse : 80 %, Pig : 80 %, Rabbit : 80 %
Characteristics This is a rabbit polyclonal antibody against TRIM23. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name TRIM23 (TRIM23 Antibody Abstract)
Background TRIM23 is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein is also a member of the ADP ribosylation factor family of guanine nucleotide-binding family of proteins. Its carboxy terminus contains an ADP-ribosylation factor domain and a guanine nucleotide binding site, while the amino terminus contains a GTPase activating protein domain which acts on the guanine nucleotide binding site. The protein localizes to lysosomes and the Golgi apparatus. It plays a role in the formation of intracellular transport vesicles, their movement from one compartment to another, and phopholipase D activation. Three alternatively spliced transcript variants for this gene have been described. The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein is also a member of the ADP ribosylation factor family of guanine nucleotide-binding family of proteins. Its carboxy terminus contains an ADP-ribosylation factor domain and a guanine nucleotide binding site, while the amino terminus contains a GTPase activating protein domain which acts on the guanine nucleotide binding site. The protein localizes to lysosomes and the Golgi apparatus. It plays a role in the formation of intracellular transport vesicles, their movement from one compartment to another, and phopholipase D activation. Three alternatively spliced transcript variants for this gene have been described.
Molecular Weight 64 kDa
Gene ID 373
NCBI Accession NM_001656, NP_001647
UniProt P36406
Research Area Signaling
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 574 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
Western Blotting (WB) image for anti-Tripartite Motif Containing 23 (TRIM23) (N-Term) antibody (ABIN404775) WB Suggested Anti-TRIM23 Antibody Titration: 0.2-1 ug/ml
ELISA Titer:
Background publications Vichi, Payne, Pacheco-Rodriguez et al.: "E3 ubiquitin ligase activity of the trifunctional ARD1 (ADP-ribosylation factor domain protein 1)." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 6, pp. 1945-50, 2005 (PubMed).

Catalog No. ABIN404775
$289.00
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