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Poly (ADP-Ribose) Polymerase Family, Member 16 (PARP16) (Middle Region) antibody

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Antigen
Synonyms PARP16, zgc:77744, ARTD15, C15orf30, pART15, BC055447, C79952, PARP-16, LRRGT00109, RGD1306243
Epitope
Middle Region
(17), (15), (2), (2), (1), (1), (1), (1), (1)
Reactivity
Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
(48), (14), (14), (1)
Host
Rabbit
(41), (7)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(30), (22), (17), (15), (11), (5)
Pubmed 2 references available
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Quantity 50 μg
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Immunogen Synthetic peptide directed towards the middle region of human PARP16
Blocking Peptide Blocking peptide for this product available: ABIN981363
Sequence PKYFVVTNNQ LLRVKYLLVY SQKPPKSRAS SQLSWFSSHW FTVMISLYLL
Predicted Reactivity Dog : 85 %, Horse : 85 %, Mouse : 85 %, Rabbit : 85 %, Rat : 85 %, Guinea pig : 75 %
Characteristics This is a rabbit polyclonal antibody against PARP16. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name PARP16
Background Poly(ADP-ribosyl)ation is an immediate DNA-damage-dependent post-translational modification of histones and other nuclear proteins that contributes to the survival of injured proliferating cells. PARP16 is a member of poly(ADP-ribose) polymerases (PARPs) family that is encoded by different genes and displaying a conserved catalytic domain in which PARP-1 (113 kDa), the founding member, and PARP-2 (62 kDa) are so far the sole enzymes whose catalytic activity has been shown to be immediately stimulated by DNA strand breaks. A large repertoire of sequences encoding novel PARPs now extends considerably the field of poly(ADP-ribosyl)ation reactions to various aspects of the cell biology including cell proliferation and cell death. Some of these new members interact with each other, share common partners and common subcellular localizations suggesting possible fine tuning in the regulation of this post-translational modification of proteins.
Molecular Weight 36 kDa
Gene ID 54956
NCBI Accession NP_060321, NM_017851
Research Area Chromatin and Nuclear Signaling
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 323 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
Western Blotting (WB) image for anti-Poly (ADP-Ribose) Polymerase Family, Member 16 (PARP16) (Middle Region) antibody (ABIN404894) WB Suggested Anti-PARP16 Antibody Titration: 0.2-1 ug/ml
ELISA Titer:
Product cited in: Di Paola, Micaroni, Di Tullio et al.: "PARP16/ARTD15 is a novel endoplasmic-reticulum-associated mono-ADP-ribosyltransferase that interacts with, and modifies karyopherin-ß1." in: PLoS ONE, Vol. 7, Issue 6, pp. e37352, 2012 (PubMed).

Background publications Amé, Spenlehauer, de Murcia: "The PARP superfamily." in: BioEssays : news and reviews in molecular, cellular and developmental biology, Vol. 26, Issue 8, pp. 882-93, 2004 (PubMed).

Catalog No. ABIN404894
$289.00
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