Potassium Voltage-Gated Channel, Shab-Related Subfamily, Member 1 (KCNB1) (Middle Region) antibody

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Antigen
Synonyms KCNB1, Kcnb1, Kcr1-1, Kv2.1, Shab, DRK1PC, DRK1, KV2.1, h-DRK1
Epitope
Middle Region
(35), (19), (19), (17), (17), (17), (15), (12), (8), (5), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Pig (Porcine), Rat (Rattus)
(148), (121), (121), (19), (6), (3), (3), (3), (1), (1), (1)
Host
Rabbit
(77), (66), (14)
Clonality
Polyclonal
Conjugate
Un-conjugated
(6), (6), (6), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB)
(109), (79), (48), (48), (43), (39), (23), (14), (6), (4), (1)
Pubmed 1 reference available
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Quantity 50 μg
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Immunogen Synthetic peptide directed towards the middle region of human KCNB1
Blocking Peptide Blocking peptide for this product available: Potassium Voltage-Gated Channel, Shab-Related Subfamily, Member 1 (KCNB1) (Middle Region) peptide (ABIN978755)
Sequence YIDADTDDEG QLLYSVDSSP PKSLPGSTSP KFSTGTRSEK NHFESSPLPT
Predicted Reactivity Human : 100 %, Bovine : 90 %, Dog : 90 %, Pig : 90 %, Guinea pig : 80 %, Horse : 80 %, Rat : 80 %, Mouse : 70 %
Characteristics This is a rabbit polyclonal antibody against KCNB1. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name KCNB1 (KCNB1 Antibody Abstract)
Background Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel and its activity is modulated by some other family members.Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel and its activity is modulated by some other family members.
Molecular Weight 96 kDa
Gene ID 3745
NCBI Accession NM_004975, NP_004966
UniProt Q14721
Research Area Neurology
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 858 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
Western Blotting (WB) image for anti-Potassium Voltage-Gated Channel, Shab-Related Subfamily, Member 1 (KCNB1) (Middle Region) antibody (ABIN404910) WB Suggested Anti-KCNB1 Antibody Titration: 0.2-1 ug/ml
ELISA Titer:
Background publications Adair, Nunn, Lewis et al.: "Single particle image reconstruction of the human recombinant Kv2.1 channel." in: Biophysical journal, Vol. 94, Issue 6, pp. 2106-14, 2008 (PubMed).

Catalog No. ABIN404910
$289.00
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