HOXB8 antibody (Middle Region)

Catalog No. ABIN405048

Product Details anti-HOXB8 Antibody

Target: HOXB8 (Homeobox B8 (HOXB8))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Dog, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HOXB8 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: FQNRRMKWKK ENNKDKFPSS KCEQEELEKQ KLERAPEAAD EGDAQKGDKK

Predicted Reactivity: Dog: 100%, Human: 100%, Mouse: 79%, Pig: 100%, Rat: 79%

Characteristics: This is a rabbit polyclonal antibody against HOXB8. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human HOXB8

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 243 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for HOXB8

Target: HOXB8 (Homeobox B8 (HOXB8))

Alternative Name: HOXB8 (HOXB8 Products)

Synonyms: HOX2 antibody, HOX2D antibody, Hox-2.4 antibody, Hox2r1a antibody, hoxa8 antibody, z-9 antibody, HBX antibody, HBX24 antibody, HOXB8 antibody, homeobox B8 antibody, homeobox protein Hox-B8 antibody, homeo box B8 antibody, homeobox B8b antibody, porcine homeobox antibody, HOXB8 antibody, Hoxb8 antibody, LOC785855 antibody, hoxb8b antibody, HOX-2.4 antibody

Background: HOXB8 belongs to the Antp homeobox family. It is a nuclear protein with a homeobox DNA-binding domain. This gene is included in a cluster of homeobox B genes located on chromosome 17. The protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with colorectal cancer. Mice that have had the murine ortholog of this gene knocked out exhibit an excessive pathologic grooming behavior. This behavior is similar to the behavior of humans suffering from the obsessive-compulsive spectrum disorder trichotillomania.This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with colorectal cancer. Mice that have had the murine ortholog of this gene knocked out exhibit an excessive pathologic grooming behavior. This behavior is similar to the behavior of humans suffering from the obsessive-compulsive spectrum disorder trichotillomania.
Alias Symbols: HOX2, HOX2D, Hox-2.4
Protein Interaction Partner: PBX3, PBX2, PBX1, MEIS1,
Protein Size: 243

Molecular Weight: 27 kDa

Gene ID: 3218

NCBI Accession: NM_024016, NP_076921

UniProt: P17481