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Nuclear Receptor Subfamily 2, Group C, Member 2 (NR2C2) (N-Term) antibody

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Antigen
Synonyms Tak1, B430101B05, C87327, TAK1, TR2R1, TR4, hTAK1, Tr4, mKIAA4145, gb:dq017625, im:6911408
Alternatives
Epitope
N-Term
(33), (28), (25), (16), (16), (16), (13), (13), (13), (13), (13), (10), (5), (5), (4), (3), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Chicken, Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Rat (Rattus), Xenopus laevis, Zebrafish (Danio rerio)
(198), (126), (122), (9), (5), (5), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Host
Rabbit
(170), (30), (4)
Clonality
Polyclonal
Conjugate
Un-conjugated
(8), (8), (8), (7), (6), (6), (6), (6), (6), (6), (6), (6), (2), (2), (2)
Application
Western Blotting (WB)
(135), (68), (53), (38), (35), (5), (3), (1), (1), (1)
Pubmed 1 reference available
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Quantity 50 μg
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Immunogen Synthetic peptide directed towards the N terminal of human NR2C2
Blocking Peptide Blocking peptide for this product available: ABIN980901
Sequence FTSLNKEKIV TDQQTGQKIQ IVTAVDASGS PKQQFILTSP DGAGTGKVIL
Predicted Reactivity Chicken : 100 %, Dog : 100 %, Guinea pig : 100 %, Horse : 100 %, Human : 100 %, Mouse : 100 %, Pig : 100 %, Rabbit : 100 %, Rat : 100 %, Zebrafish : 90 %, Bovine : 80 %
Characteristics This is a rabbit polyclonal antibody against NR2C2. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name NR2C2 (NR2C2 Antibody Abstract)
Background Members of the nuclear hormone receptor family, such as NR2C2, act as ligand-activated transcription factors. The proteins have an N-terminal transactivation domain, a central DNA-binding domain with 2 zinc fingers, and a ligand-binding domain at the C terminus. The activated receptor/ligand complex is translocated to the nucleus where it binds to hormone response elements of target genes. Members of the nuclear hormone receptor family, such as NR2C2, act as ligand-activated transcription factors. The proteins have an N-terminal transactivation domain, a central DNA-binding domain with 2 zinc fingers, and a ligand-binding domain at the C terminus. The activated receptor/ligand complex is translocated to the nucleus where it binds to hormone response elements of target genes (Yoshikawa et al., 1996 [PubMed 8661150]).
Molecular Weight 67 kDa
Gene ID 7182
NCBI Accession NP_003289, NM_003298
UniProt P49116
Research Area Chromatin and Nuclear Signaling
Pathways Nuclear Receptor Transcription Pathway
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 615 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
Western Blotting (WB) image for anti-Nuclear Receptor Subfamily 2, Group C, Member 2 (NR2C2) (N-Term) antibody (ABIN405149) anti-Nuclear Receptor Subfamily 2, Group C, Member 2 (NR2C2) (N-Term) antibody
Background publications Bouwmeester, Bauch, Ruffner et al.: "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. ..." in: Nature cell biology, Vol. 6, Issue 2, pp. 97-105, 2004 (PubMed).

Catalog No. ABIN405149
$289.00
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