TRIM68 antibody (Middle Region)

Catalog No. ABIN405219

Product Details anti-TRIM68 Antibody

Target: TRIM68 (Tripartite Motif Containing 68 (TRIM68))

Binding Specificity: Middle Region

Reactivity: Human, Rat, Mouse, Cow, Horse, Pig, Dog, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRIM68 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: VIRLRKGNEY RAGTDEYPIL SLPVPPRRVG IFVDYEAHDI SFYNVTDCGS

Predicted Reactivity: Cow: 100%, Dog: 79%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 79%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against TRIM68. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human TRIM68

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 485 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for TRIM68

Target: TRIM68 (Tripartite Motif Containing 68 (TRIM68))

Alternative Name: TRIM68 (TRIM68 Products)

Synonyms: GC109 antibody, RNF137 antibody, SS-56 antibody, SS56 antibody, AI894158 antibody, F730114J12Rik antibody, Rnf137 antibody, TRIM68 antibody, tripartite motif containing 68 antibody, tripartite motif-containing 68 antibody, E3 ubiquitin-protein ligase TRIM68 antibody, TRIM68 antibody, Trim68 antibody, LOC100053519 antibody

Background: The protein encoded by TRIM68 contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. TRIM68 is expressed in many cancer cell lines. Its expression in normal tissues, however, was found to be restricted to prostate. TRIM68 was also found to be differentially expressed in androgen-dependent versus androgen-independent prostate cancer cells. The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is expressed in many cancer cell lines. Its expression in normal tissues, however, was found to be restricted to prostate. This gene was also found to be differentially expressed in androgen-dependent versus androgen-independent prostate cancer cells.
Alias Symbols: FLJ10369, MGC126176, RNF137, SS-56, SS56, GC109
Protein Interaction Partner: NLRP1, TFG, VIM, UBC, HSP90B1, HNRNPL, BTN1A1, UBE2D3, UBE2U, KAT5, AR,
Protein Size: 485

Molecular Weight: 56 kDa

Gene ID: 55128

NCBI Accession: NM_018073, NP_060543

UniProt: Q6AZZ1

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling