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KDM6A antibody (Middle Region)

KDM6A Reactivity: Human, Mouse, Rat, Dog, Cow, Zebrafish (Danio rerio), Guinea Pig, Horse, Rabbit WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN405243
  • Target See all KDM6A Antibodies
    KDM6A (Lysine (K)-Specific Demethylase 6A (KDM6A))
    Binding Specificity
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivity
    • 32
    • 11
    • 9
    • 5
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    Human, Mouse, Rat, Dog, Cow, Zebrafish (Danio rerio), Guinea Pig, Horse, Rabbit
    Host
    • 23
    • 13
    Rabbit
    Clonality
    • 23
    • 13
    Polyclonal
    Conjugate
    • 25
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This KDM6A antibody is un-conjugated
    Application
    • 23
    • 14
    • 8
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Sequence
    KTYIVHCQDC ARKTSGNLEN FVVLEQYKME DLMQVYDQFT LAPPLPSASS
    Predicted Reactivity
    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%
    Characteristics
    This is a rabbit polyclonal antibody against UTX. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human UTX
    Top Product
    Discover our top product KDM6A Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 1401 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    KDM6A (Lysine (K)-Specific Demethylase 6A (KDM6A))
    Alternative Name
    UTX (KDM6A Products)
    Synonyms
    KABUK2 antibody, UTX antibody, bA386N14.2 antibody, Utx antibody, si:ch211-222m21.1 antibody, utx antibody, kdm6a antibody, tutx antibody, uty antibody, xtutx antibody, lysine demethylase 6A antibody, lysine-specific demethylase 6A antibody, lysine (K)-specific demethylase 6A antibody, lysine demethylase 6A S homeolog antibody, KDM6A antibody, LOC100539898 antibody, Kdm6a antibody, kdm6a antibody, kdm6a.S antibody
    Background
    UTX is a histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. It demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27'. UTX plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of 'Lys-27' of histone H3 is concomitent with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A.
    Alias Symbols: DKFZp686A03225, MGC141941, bA386N14.2, UTX, KABUK2
    Protein Interaction Partner: KMT2D, WDR5, ASH2L, RBBP5, SMAD9, HIST2H3C, SRF, SMARCA4, GATA4, NKX2-5, TBX5, UBC, HIST1H3A, WDR82, PAXIP1, NCOA6, TLE1, PROSER1, KMT2C, N4BP2, PPP6R3, ZNF281, HIST3H3,
    Protein Size: 1401
    Molecular Weight
    154 kDa
    Gene ID
    7403
    NCBI Accession
    NM_021140, NP_066963
    UniProt
    O15550
    Pathways
    Tube Formation, Warburg Effect
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