Transglutaminase 1, Keratinocyte (TGM1) (N-Term) antibody

Details for Product No. ABIN405419
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Antigen
Synonyms TGM1, fa12g12, wu:fa12g12, zgc:112355, ARCI1, ICR2, KTG, LI, LI1, TGASE, TGK, 2310004J08Rik, Tgase1
Epitope
N-Term
(5), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Rabbit, Mouse (Murine), Rat (Rattus), Cow (Bovine), Dog (Canine), Human
(35), (8), (6), (1), (1), (1)
Host
Rabbit
(33), (6), (1), (1)
Clonality
Polyclonal
Application
Western Blotting (WB)
(37), (24), (11), (9), (9), (6), (5), (4)
Pubmed 1 reference available
Quantity 50 µg
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Catalog No. ABIN405419
289.00 $
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Immunogen Synthetic peptide directed towards the N terminal of human TGM1
Sequence RGSSSGTRRP GSRGSDSRRP VSRGSGVNAA GDGTIREGML VVNGVDLLSS
Predicted Reactivity Guinea pig : 100 %, Human : 100 %, Mouse : 100 %, Pig : 100 %, Rat : 100 %, Bovine : 90 %, Dog : 90 %, Rabbit : 90 %
Characteristics This is a rabbit polyclonal antibody against TGM1. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name TGM1
Background TGM1 is a membrane protein that catalyzes the addition of an alkyl group from an akylamine to a glutamine residue of a protein, forming an alkylglutamine in the protein. This protein alkylation leads to crosslinking of proteins and catenation of polyamines to proteins. This gene contains either one or two copies of a 22 nt repeat unit in its 3' UTR. Mutations in this gene have been associated with autosomal recessive lamellar ichthyosis (LI) and nonbullous congenital ichthyosiform erythroderma (NCIE).The protein encoded by this gene is a membrane protein that catalyzes the addition of an alkyl group from an akylamine to a glutamine residue of a protein, forming an alkylglutamine in the protein. This protein alkylation leads to crosslinking of proteins and catenation of polyamines to proteins. This gene contains either one or two copies of a 22 nt repeat unit in its 3' UTR. Mutations in this gene have been associated with autosomal recessive lamellar ichthyosis (LI) and nonbullous congenital ichthyosiform erythroderma (NCIE).
Molecular Weight 90 kDa
Gene ID 7051
NCBI Accession NM_000359, NP_000350
UniProt P22735
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 817 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Background publications Marietta, Camilleri, Castro et al.: "Transglutaminase autoantibodies in dermatitis herpetiformis and celiac sprue." in: The Journal of investigative dermatology, Vol. 128, Issue 2, pp. 332-5, 2008 (PubMed).

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