Keratin 10 antibody (N-Term)
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- Target See all Keratin 10 (KRT10) Antibodies
- Keratin 10 (KRT10)
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Binding Specificity
- N-Term
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Reactivity
- Human, Mouse, Rat, Dog, Rabbit, Cow, Pig, Horse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This Keratin 10 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- EKVTMQNLND RLASYLDKVR ALEESNYELE GKIKEWYEKH GNSHQGEPRD
- Predicted Reactivity
- Cow: 93%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 86%, Rabbit: 100%, Rat: 100%
- Characteristics
- This is a rabbit polyclonal antibody against KRT10. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N terminal region of human KRT10
- Top Product
- Discover our top product KRT10 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 584 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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Mild recessive bullous congenital ichthyosiform erythroderma due to a previously unidentified homozygous keratin 10 nonsense mutation." in: The Journal of investigative dermatology, Vol. 128, Issue 7, pp. 1648-52, (2008) (PubMed).
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Mild recessive bullous congenital ichthyosiform erythroderma due to a previously unidentified homozygous keratin 10 nonsense mutation." in: The Journal of investigative dermatology, Vol. 128, Issue 7, pp. 1648-52, (2008) (PubMed).
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- Target
- Keratin 10 (KRT10)
- Alternative Name
- KRT10 (KRT10 Products)
- Background
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KRT10 is a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in the gene encoding KRT10 are associated with epidermolytic hyperkeratosis. This gene encodes a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: CK10, K10, KPP, BIE, EHK, BCIE
Protein Interaction Partner: UBC, Fbxl16, ADRB2, PAN2, Nphp4, Iqcb1, Cep290, Nphp1, Invs, VCAM1, SRC, ITGA4, FN1, ALB, MAGOH, TRAF3IP1, EIF4A3, AHNAK2, KRT2, KRT1, ELAVL1, UBASH3B, SHC1, PIK3R2, INPPL1, GRB2, EPS15, CRK, AP2M1, CBL, NEDD8, CAND1, DCUN1D1, COPS5, COPS6, CUL1, CUL2, CU
Protein Size: 584 - Molecular Weight
- 59 kDa
- Gene ID
- 3858
- NCBI Accession
- NM_000421, NP_000412
- UniProt
- P13645
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