anti-Angiotensin II Type-1 Receptor antibody (Angiotensin II Receptor, Type 1) (N-Term)

Details for Product anti-AGTR1 Antibody No. ABIN405448, Supplier: Login to see New
New
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Synonyms
AGTR1B, AT1, XAT-1, agtr1-A, agtr1.2, at2, AGTR2, zgc:113016, at2r, atgr2, mrx88, AG2S, AGTR1A, AT1AR, AT1B, AT1BR, AT1R, AT2R1, AT2R1A, AT2R1B, HAT1R, at1, AT1-R, 1810074K20Rik, AI551199, AT1a, Agtr- ... show more
AGTR1B, AT1, XAT-1, agtr1-A, agtr1.2, at2, AGTR2, zgc:113016, at2r, atgr2, mrx88, AG2S, AGTR1A, AT1AR, AT1B, AT1BR, AT1R, AT2R1, AT2R1A, AT2R1B, HAT1R, at1, AT1-R, 1810074K20Rik, AI551199, AT1a, Agtr-1a, Agtr1, Angtr-1a, AT3, AT1R, Agtr-1b, Angtr-1b, AGTR1 show less
Alternatives
Epitope
N-Term
(15), (13), (6), (4), (3), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Reactivity
Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Pig (Porcine), Rabbit, Rat (Rattus)
(83), (58), (47), (4), (2), (1), (1), (1), (1), (1)
Host
Rabbit
(69), (16), (6), (5), (4)
Clonality
Polyclonal
Conjugate
This Angiotensin II Type-1 Receptor antibody is un-conjugated
(3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(83), (57), (18), (13), (12), (10), (6), (5), (2), (1), (1)
Pubmed 1 reference available
ProductDetails: Supplier Login to see New
ProductDetails: Supplier Product Number Login to see New
Quantity 50 μg
Options
Shipping to United States ( )
Availability Will be delivered in 2 to 3 Business Days
Immunogen Synthetic peptide directed towards the N terminal of human AGTR1
Sequence ILNSSTEDGI KRIQDDCPKA GRHNYIFVMI PTLYSIIFVV GIFGNSLVVI
Predicted Reactivity Bovine : 100 %, Dog : 100 %, Guinea pig : 100 %, Human : 100 %, Rabbit : 100 %, Sheep : 100 %, Mouse : 90 %, Pig : 90 %
Characteristics This is a rabbit polyclonal antibody against AGTR1. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name AGTR1 (AGTR1 Antibody Abstract)
Background Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. AGTR1 is the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. AGTR1 may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed, however, it is now believed that there is only one type 1 receptor gene in humans.Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed, however, it is now believed that there is only one type 1 receptor gene in humans. At least five transcript variants have been described for this gene. Additional variants have been described but their full-length nature has not been determined. The entire coding sequence is contained in the terminal exon and is present in all transcript variants.
Molecular Weight 41 kDa
Gene ID 185
NCBI Accession NM_004835, NP_004826
UniProt P30556
Pathways JAK-STAT Signaling, ACE Inhibitor Pathway
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 359 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
Western Blotting (WB) image for anti-Angiotensin II Type-1 Receptor antibody (Angiotensin II Receptor, Type 1) (N-Term) (ABIN405448) WB Suggested Anti-AGTR1 Antibody Titration: 0.2-1 ug/ml
ELISA Titer:
Background publications Kurland, Hallberg, Melhus et al.: "The relationship between the plasma concentration of irbesartan and the antihypertensive response is disclosed by an angiotensin II type 1 receptor polymorphism: results from the Swedish Irbesartan Left Ventricular Hypertrophy Investigation vs. Atenolol (" in: American journal of hypertension, Vol. 21, Issue 7, pp. 836-9, 2008 (PubMed).

Catalog No. ABIN405448
$289.00
Plus shipping costs $45.00

Order hotline:

  • +1 877 302 8632
  • +1 888 205 9894 (TF)
Did you look for something else?