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Cytokeratin 1 antibody (Middle Region)

KRT1 Reactivity: Human, Rat, Rabbit, Dog WB, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN405458
  • Target See all Cytokeratin 1 (KRT1) Antibodies
    Cytokeratin 1 (KRT1) (Keratin 1 (KRT1))
    Binding Specificity
    • 21
    • 16
    • 16
    • 5
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivity
    • 97
    • 57
    • 43
    • 24
    • 16
    • 13
    • 9
    • 8
    • 7
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Rat, Rabbit, Dog
    Host
    • 77
    • 41
    • 1
    Rabbit
    Clonality
    • 70
    • 49
    Polyclonal
    Conjugate
    • 49
    • 15
    • 10
    • 7
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    This Cytokeratin 1 antibody is un-conjugated
    Application
    • 82
    • 54
    • 32
    • 30
    • 27
    • 27
    • 26
    • 19
    • 17
    • 14
    • 13
    • 8
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Sequence
    GSYGSGSSSG GYRGGSGGGG GGSSGGRGSG GGSSGGSIGG RGSSSGGVKS
    Predicted Reactivity
    Dog: 86%, Human: 100%, Rabbit: 93%, Rat: 93%
    Characteristics
    This is a rabbit polyclonal antibody against KRT1. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human KRT1
    Top Product
    Discover our top product KRT1 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 644 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    Cytokeratin 1 (KRT1) (Keratin 1 (KRT1))
    Alternative Name
    KRT1 (KRT1 Products)
    Synonyms
    CK1 antibody, EHK antibody, EHK1 antibody, EPPK antibody, K1 antibody, KRT1A antibody, NEPPK antibody, Krt-2.1 antibody, Krt2-1 antibody, Krt86 antibody, KRT1 antibody, Kb1 antibody, KER1 antibody, CK-1 antibody, Keratin-1 antibody, keratin 1 antibody, KRT1 antibody, Krt1 antibody
    Background
    KRT1 is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the spinous and granular layers of the epidermis with family member KRT10 and mutations in these genes have been associated with bullous congenital ichthyosiform erythroderma.The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the spinous and granular layers of the epidermis with family member KRT10 and mutations in these genes have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
    Alias Symbols: CK1, EHK1, K1, KRT1A, EHK, EPPK, NEPPK
    Protein Interaction Partner: MDM2, LGR4, EED, ESR1, ADRB2, PAN2, Iqcb1, Nphp4, Cep290, Nphp1, Invs, GRDX, VCAM1, UBC, ITGA4, FN1, CDH1, APOA1, ALB, MAGOH, EIF4A3, KRT10, KRT9, KRT2, SLC25A5, SHC1, PIK3R2, INPPL1, GRB2, EPS15, CRK, AP2M1, CBL, UBASH3B, NEDD8, CAND1, DCUN1D1, COPS5, CO
    Protein Size: 644
    Molecular Weight
    66 kDa
    Gene ID
    3848
    NCBI Accession
    NM_006121, NP_006112
    UniProt
    P04264
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