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Keratin 1 (KRT1) (Middle Region) antibody

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Antigen
Synonyms KRT1, CK1, EHK, EHK1, EPPK, K1, KRT1A, NEPPK, Krt-2.1, Krt2-1, Krt86, Kb1, KER1, CK-1, Keratin-1
Epitope
Middle Region
(8), (7), (6), (5), (5), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Reactivity
Dog (Canine), Human
(57), (20), (18)
Host
Rabbit
(55), (19), (3)
Clonality
Polyclonal
Conjugate
Un-conjugated
(9), (3)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(58), (46), (28), (25), (14), (11), (5), (5), (1), (1), (1)
Pubmed 1 reference available
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Quantity 50 μg
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Immunogen Synthetic peptide directed towards the middle region of human KRT1
Blocking Peptide Blocking peptide for this product available: ABIN979113
Sequence GSYGSGSSSG GYRGGSGGGG GGSSGGRGSG GGSSGGSIGG RGSSSGGVKS
Predicted Reactivity Rabbit : 92 %
Characteristics This is a rabbit polyclonal antibody against KRT1. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name KRT1 (KRT1 Antibody Abstract)
Background KRT1 is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the spinous and granular layers of the epidermis with family member KRT10 and mutations in these genes have been associated with bullous congenital ichthyosiform erythroderma.The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the spinous and granular layers of the epidermis with family member KRT10 and mutations in these genes have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.
Molecular Weight 66 kDa
Gene ID 3848
NCBI Accession NP_006112, NM_006121
UniProt P04264
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 644 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
Western Blotting (WB) image for anti-Keratin 1 (KRT1) (Middle Region) antibody (ABIN405458) anti-Keratin 1 (KRT1) (Middle Region) antibody
Immunohistochemistry (IHC) image for anti-Keratin 1 (KRT1) (Middle Region) antibody (ABIN405458) anti-Keratin 1 (KRT1) (Middle Region) antibody (Image 2)
Immunohistochemistry (IHC) image for anti-Keratin 1 (KRT1) (Middle Region) antibody (ABIN405458) anti-Keratin 1 (KRT1) (Middle Region) antibody (Image 3)
Background publications Schweizer, Bowden, Coulombe et al.: "New consensus nomenclature for mammalian keratins." in: The Journal of cell biology, Vol. 174, Issue 2, pp. 169-74, 2006 (PubMed).

Catalog No. ABIN405458
$289.00
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