anti-KREMEN1 antibody (Kringle Containing Transmembrane Protein 1) (N-Term)

Details for Product anti-KREMEN1 Antibody No. ABIN405712, Supplier: Login to see New
New
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Synonyms KREMEN1, krm1, kremen, kremem1, KREMEN, KRM1, AV002070, Kremen, Krm1, si:ct737139.1, si:dkeyp-7c9.1
Alternatives
Epitope
N-Term
(44), (19), (14), (8), (3), (2), (2), (2), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus), Xenopus laevis
(72), (13), (9), (1), (1)
Host
Rabbit
(67), (5), (4)
Clonality
Polyclonal
Conjugate
This KREMEN1 antibody is un-conjugated
(6), (6), (6), (6), (6), (6)
Application
Western Blotting (WB)
(57), (57), (29), (15), (7), (3), (2), (1)
Pubmed 1 reference available
Supplier Login to see New
Catalog number from supplier Login to see New
Quantity 50 μg
Options
Shipping to United States ( )
Availability Will be delivered in 2 to 3 Business Days
Immunogen Synthetic peptide directed towards the N terminal of human KREMEN1
Blocking Peptide Blocking peptide for this product available: Kringle Containing Transmembrane Protein 1 (KREMEN1) (N-Term) peptide (ABIN979111)
Sequence WKYCEIPACQ MPGNLGCYKD HGNPPPLTGT SKTSNKLTIQ TCISFCRSQR
Predicted Reactivity Human :100 %,   Mouse :100 %,   Rat :100 %,   Western clawed frog :90 %,   African clawed frog :90 %,  
Characteristics This is a rabbit polyclonal antibody against KREMEN1. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name KREMEN1 (KREMEN1 Antibody Abstract)
Background KREMEN1 is a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. It is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains.This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene.
Molecular Weight 50 kDa
Gene ID 83999
NCBI Accession NP_001034659, NM_001039570
UniProt Q96MU8
Research Area Stem Cells, Wnt
Pathways WNT Signaling
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 475 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
Western Blotting (WB) image for anti-KREMEN1 antibody (Kringle Containing Transmembrane Protein 1) (N-Term) (ABIN405712) WB Suggested Anti-KREMEN1 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: <...
Background publications Mao, Wu, Davidson et al.: "Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling." in: Nature, Vol. 417, Issue 6889, pp. 664-7, 2002 (PubMed).

Catalog No. ABIN405712
$289.00
Plus shipping costs $45.00

Order hotline:

  • +1 877 302 8632
  • +1 888 205 9894 (TF)