Protocadherin gamma Subfamily C, 3 (PCDHGC3) (C-Term) antibody

Catalog No. ABIN405732

Product Details

Target: Protocadherin gamma Subfamily C, 3 (PCDHGC3)

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Guinea Pig, Horse, Cow

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB)

Sequence: IKDNGEPSLS TTATLTVSVT EDSPEARAEF PSGSAPREQK KNLTFYLLLS

Predicted Reactivity: Cow: 92%, Guinea Pig: 85%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against PCDHGC3. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human PCDHGC3

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 934 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details

Target: Protocadherin gamma Subfamily C, 3 (PCDHGC3)

Alternative Name: PCDHGC3 (PCDHGC3 Products)

Synonyms: PC43 antibody, PCDH-GAMMA-C3 antibody, PCDH2 antibody, Pcdh2 antibody, PCDHGA11 antibody, PCDHGC5 antibody, protocadherin gamma subfamily C, 3 antibody, PCDHGC3 antibody, Pcdhgc3 antibody

Background: This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. PCDHGC3 is a potential calcium-dependent cell-adhesion protein. It may be involved in the establishment and maintenance of specific neuronal connections in the brain.This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.
Alias Symbols: PC43, PCDH-GAMMA-C3, PCDH2
Protein Interaction Partner: UBC, MFSD3, HGD, APP,
Protein Size: 934

Molecular Weight: 98 kDa

Gene ID: 5098

NCBI Accession: NM_002588, NP_002579

UniProt: Q9UN70