anti-Dystrobrevin beta antibody (Dystrobrevin, beta) (C-Term)

Details for Product anti-DTNB Antibody No. ABIN405811, Supplier: Login to see New
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Antigen
Synonyms DTNB, GDTN, dtnb, dtng, gtnb, wu:fc61h11, bdtn, btnb, G2, LC2f, MLC-2, MLC2, Myl2, Myolc1
Epitope
C-Term
(13), (4), (3), (3), (2), (2), (1), (1)
Reactivity
Chicken, Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Rat (Rattus), Xenopus laevis, Zebrafish (Danio rerio)
(72), (28), (25), (6), (2)
Host
Rabbit
(45), (27)
Clonality
Polyclonal
Conjugate
This Dystrobrevin beta antibody is un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(43), (16), (14), (13), (11), (10), (7), (5), (4), (1)
Pubmed 1 reference available
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Quantity 50 μg
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Immunogen Synthetic peptide directed towards the C terminal of human DTNB
Sequence ASQPTPEKAQ QNPTLLAELR LLRQRKDELE QRMSALQESR RELMVQLEEL
Predicted Reactivity Bovine : 100 %, Chicken : 100 %, Dog : 100 %, Guinea pig : 100 %, Horse : 100 %, Human : 100 %, Mouse : 100 %, Rat : 100 %, Zebrafish : 100 %
Characteristics This is a rabbit polyclonal antibody against DTNB. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name DTNB (DTNB Antibody Abstract)
Background DTNB is dystrobrevin beta, a component of the dystrophin-associated protein complex (DPC). The DPC consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and dystrobrevin alpha and beta. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Dystrobrevin beta is thought to interact with syntrophin and the DP71 short form of dystrophin.This gene encodes dystrobrevin beta, a component of the dystrophin-associated protein complex (DPC). The DPC consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and dystrobrevin alpha and beta. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Dystrobrevin beta is thought to interact with syntrophin and the DP71 short form of dystrophin. Alternatively spliced transcript variants encoding different isoforms have been identified.
Molecular Weight 64 kDa
Gene ID 1838
NCBI Accession NM_033148, NP_149160
UniProt O60941
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 567 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
Western Blotting (WB) image for anti-Dystrobrevin beta antibody (Dystrobrevin, beta) (C-Term) (ABIN405811) anti-Dystrobrevin, beta (DTNB) (C-Term) antibody
Background publications Nazarian, Starcevic, Spencer et al.: "Reinvestigation of the dysbindin subunit of BLOC-1 (biogenesis of lysosome-related organelles complex-1) as a dystrobrevin-binding protein." in: The Biochemical journal, Vol. 395, Issue 3, pp. 587-98, 2006 (PubMed).

Catalog No. ABIN405811
$289.00
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