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Details for Product No. ABIN406006

serine Palmitoyltransferase, Long Chain Base Subunit 2 (SPTLC2) (N-Term) antibody

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Antigen
Synonyms HSN1C, LCB2, LCB2A, NSAN1C, SPT2, hLCB2a, AI173915, mKIAA0526, Pomt2, sptlc2, zgc:110661
Epitope
»Alternatives N-Term
Reactivity
»Alternatives Mouse (Murine), Rat (Rattus), Cow (Bovine), Zebrafish (Danio rerio), Xenopus laevis, Dog (Canine), Human, Chicken
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN406006
Quantity 50 µg
Price
289.00 $   Plus shipping costs $45.00
Shipping to
Availability Will be delivered in 2 to 3 Business Days
Immunogen The immunogen for anti-SPTLC2 antibody: synthetic peptide directed towards the N terminal of human SPTLC2
Sequence VLTYVGYGVLTLFGYLRDFLRYWRIEKCHHATEREEQKDF VSLYQDFENF
Predicted Reactivity Bovine : 100%, Guinea pig : 100%, Human : 100%, Mouse : 100%, Rabbit : 100%, Rat : 100%, Zebrafish : 100%, Horse : 92%, African clawed frog : 90%, Dog : 85%, Chicken : 76%
Characteristics This is a rabbit polyclonal antibody against SPTLC2. It was validated on Western Blot using a cell lysate as a positive control. We strive to provide antibodies covering each member of a whole protein family of your interest.
Purification Affinity Purified
Alternative Name SPTLC2
Background SPTLC2 is a long chain base subunit of serine palmitoyltransferase. Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It catalyzes the pyridoxal-5-prime-phosphate-dependent condensation of L-serine and palmitoyl-CoA to 3-oxosphinganine. Mutations in this gene were identified in patients with hereditary sensory neuropathy type I.This gene encodes a long chain base subunit of serine palmitoyltransferase. Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It catalyzes the pyridoxal-5-prime-phosphate-dependent condensation of L-serine and palmitoyl-CoA to 3-oxosphinganine. Mutations in this gene were identified in patients with hereditary sensory neuropathy type I. Alternatively spliced variants encoding different isoforms have been identified.
Molecular Weight 63kDa
Gene ID 9517
NCBI Accession NP_004854, NM_004863
UniProt O15270
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water
Concentration 1mg/mL
Buffer Final anti-SPTLC2 antibody concentration is 1 mg/mL in PBS buffer.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Background publications Hornemann, Wei, von Eckardstein: "Is the mammalian serine palmitoyltransferase a high-molecular-mass complex?" in: The Biochemical journal, Vol. 405, Issue 1, pp. 157-64, 2007 (PubMed).

Alternatives for antigen "serine Palmitoyltransferase, Long Chain Base Subunit 2 (SPTLC2)", type "Antibodies"
Hosts (40), (1)
Reactivities (40), (31), (26), (19), (17), (17), (2)
Applications (25), (17), (15), (10), (7), (1), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (8), (3), (2), (1), (1), (1), (1)
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