serine Palmitoyltransferase, Long Chain Base Subunit 2 (SPTLC2) (N-Term) antibody

Details for Product No. ABIN406006
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Antigen
Synonyms Dcpp-2, EG630537, SPT-2, LCB2, LCB2a, SPTLC2, HSN1C, LCB2A, NSAN1C, SPT2, hLCB2a, AI173915, mKIAA0526, Pomt2, sptlc2, zgc:110661
Epitope
N-Term
(15), (8), (3), (2), (1), (1), (1), (1), (1)
Reactivity
Mouse (Murine), Rat (Rattus), Cow (Bovine), Zebrafish (Danio rerio), Xenopus laevis, Dog (Canine), Human, Chicken
(54), (32), (27), (19), (17), (17), (2)
Host
Rabbit
(53), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(40), (25), (14), (8), (1), (1), (1)
Pubmed 1 reference available
Quantity 50 µg
Options
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Catalog No. ABIN406006
289.00 $
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Immunogen Synthetic peptide directed towards the N terminal of human SPTLC2
Sequence VLTYVGYGVL TLFGYLRDFL RYWRIEKCHH ATEREEQKDF VSLYQDFENF
Predicted Reactivity Bovine : 100 %, Guinea pig : 100 %, Human : 100 %, Mouse : 100 %, Rabbit : 100 %, Rat : 100 %, Zebrafish : 100 %, Horse : 90 %, African clawed frog : 90 %, Dog : 80 %, Chicken : 70 %
Characteristics This is a rabbit polyclonal antibody against SPTLC2. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name SPTLC2
Background SPTLC2 is a long chain base subunit of serine palmitoyltransferase. Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It catalyzes the pyridoxal-5-prime-phosphate-dependent condensation of L-serine and palmitoyl-CoA to 3-oxosphinganine. Mutations in this gene were identified in patients with hereditary sensory neuropathy type I.This gene encodes a long chain base subunit of serine palmitoyltransferase. Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It catalyzes the pyridoxal-5-prime-phosphate-dependent condensation of L-serine and palmitoyl-CoA to 3-oxosphinganine. Mutations in this gene were identified in patients with hereditary sensory neuropathy type I. Alternatively spliced variants encoding different isoforms have been identified.
Molecular Weight 63 kDa
Gene ID 9517
NCBI Accession NP_004854, NM_004863
UniProt O15270
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 562 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-serine Palmitoyltransferase, Long Chain Base Subunit 2 (SPTLC2) (N-Term) antibody WB Suggested Anti-SPTLC2 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: HepG2 cell lysate
Background publications Hornemann, Wei, von Eckardstein: "Is the mammalian serine palmitoyltransferase a high-molecular-mass complex?" in: The Biochemical journal, Vol. 405, Issue 1, pp. 157-64, 2007 (PubMed).

Validation Images
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