PCDHA12 antibody (N-Term)

Catalog No. ABIN406045

Product Details anti-PCDHA12 Antibody

Target: PCDHA12 (Protocadherin alpha 12 (PCDHA12))

Binding Specificity: N-Term

Reactivity: Human, Rat, Mouse, Cow, Dog, Guinea Pig, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PCDHA12 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: EVIVDRPLQV FHVDVEVKDI NDNPPVFRER EQKVPVSESA PLDSHFPLEG

Predicted Reactivity: Cow: 100%, Dog: 92%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 83%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against PCDHA12. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PCDHA12

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 941 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PCDHA12

Target: PCDHA12 (Protocadherin alpha 12 (PCDHA12))

Alternative Name: PCDHA12 (PCDHA12 Products)

Synonyms: PCDH-ALPHA12 antibody, Pcdha11 antibody, rCNRv12 antibody, Cnr5 antibody, Crnr5 antibody, Pcdha13 antibody, CNRv12 antibody, PCDHA12 antibody, protocadherin alpha 12 antibody, protocadherin alpha-12 antibody, PCDHA12 antibody, Pcdha12 antibody, LOC102147933 antibody

Background: PCDHA12 is a potential calcium-dependent cell-adhesion protein. PCDHA12 may be involved in the establishment and maintenance of specific neuronal connections in the brain.This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.
Alias Symbols: MGC138485, MGC141932, PCDH-ALPHA12
Protein Size: 941

Molecular Weight: 99 kDa

Gene ID: 56137

NCBI Accession: NM_018903, NP_061726

UniProt: Q9UN75