IMPDH1 antibody (Middle Region)

Catalog No. ABIN406394

Product Details anti-IMPDH1 Antibody

Target: IMPDH1 (Inosine 5'-Phosphate Dehydrogenase 1 (IMPDH1))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Zebrafish (Danio rerio), Rabbit, Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IMPDH1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: KKGKLPIVND CDELVAIIAR TDLKKNRDYP LASKDSQKQL LCGAAVGTRE

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 79%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against IMPDH1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human IMPDH1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 563 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for IMPDH1

Target: IMPDH1 (Inosine 5'-Phosphate Dehydrogenase 1 (IMPDH1))

Alternative Name: IMPDH1 (IMPDH1 Products)

Synonyms: IMPD antibody, IMPD1 antibody, LCA11 antibody, RP10 antibody, sWSS2608 antibody, B930086D20Rik antibody, IMPD 1 antibody, IMPDH 1 antibody, D3 antibody, IMPD 1b antibody, IMPDH 1b antibody, IMPDH1 antibody, id:ibd5035 antibody, si:dkey-31f5.7 antibody, wu:fa09h11 antibody, wu:fa99c03 antibody, zgc:113446 antibody, imp antibody, imp1 antibody, imp2 antibody, IMPD 1a antibody, IMPDH 1a antibody, zgc:91911 antibody, inosine monophosphate dehydrogenase 1 antibody, inosine-5'-monophosphate dehydrogenase 1 antibody, IMP (inosine 5'-monophosphate) dehydrogenase 1b antibody, IMP (inosine 5'-monophosphate) dehydrogenase 1 antibody, IMP (inosine 5'-monophosphate) dehydrogenase 1a antibody, IMPDH1 antibody, Impdh1 antibody, LOC100442769 antibody, impdh1 antibody, impdh1b antibody, impdh1.L antibody, impdh1a antibody

Background: IMPDH1 acts as a homotetramer to regulate cell growth. It is an enzyme that catalyzes the synthesis of xanthine monophosphate (XMP) from inosine-5'-monophosphate (IMP). This is the rate-limiting step in the de novo synthesis of guanine nucleotides. Defects in this gene are a cause of retinitis pigmentosa type 10 (RP10).
Alias Symbols: DKFZp781N0678, IMPD, IMPD1, LCA11, RP10, sWSS2608
Protein Interaction Partner: UBC, LAMP2, IMPDH2, XRCC6, GMNN, HTRA1, DDX3X, SUMO4,
Protein Size: 563

Molecular Weight: 62 kDa

Gene ID: 3614

NCBI Accession: NM_183243, NP_899066

UniProt: P20839

Pathways: Ribonucleoside Biosynthetic Process