Integrin beta 3 Binding Protein (Beta3-Endonexin) (ITGB3BP) (N-Term) antibody

Details for Product No. ABIN406460
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Synonyms CENP-R, CENPR, HSU37139, NRIF3, TAP20, 4930471O16Rik, AU022583
(4), (2), (2), (1), (1)
(28), (2), (2)
(20), (8)
Western Blotting (WB)
(26), (11), (10), (4)
Pubmed 1 reference available
Quantity 50 μg
Shipping to United States ( )
Availability Will be delivered in 2 to 3 Business Days
Immunogen Synthetic peptide directed towards the N terminal of human ITGB3BP
Predicted Reactivity Human : 100 %
Characteristics This is a rabbit polyclonal antibody against ITGB3BP. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name ITGB3BP (ITGB3BP Antibody Abstract)
Background ITGB3BP is a transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. ITGB3BP acts as a transcriptional corepressor via its interaction with the NFKB1 NF-kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. It induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. ITGB3BP may also act as an inhibitor of cyclin A-associated kinase. ITGB3BP may be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.
Molecular Weight 20 kDa
Gene ID 23421
NCBI Accession NM_014288, NP_055103
UniProt Q13352
Research Area Chromatin and Nuclear Signaling, Cell Cycle
Application Notes Optimal working dilutions should be determined experimentally by the investigator.

Antigen size: 177 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
Western Blotting (WB) image for anti-Integrin beta 3 Binding Protein (Beta3-Endonexin) (ITGB3BP) (N-Term) antibody (ABIN406460) WB Suggested Anti-ITGB3BP Antibody Titration: 0.2-1 ug/ml
ELISA Titer: <...
Background publications Gregory, Barlow, McLay et al.: "The DNA sequence and biological annotation of human chromosome 1. ..." in: Nature, Vol. 441, Issue 7091, pp. 315-21, 2006 (PubMed).

Catalog No. ABIN406460
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