Homeobox A11 (HOXA11) (Middle Region) antibody

Details for Product No. ABIN406665
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Antigen
Synonyms Hoxa10, RGD1564605, RGD1566402, HOX1, HOX1I, Hox-1.9, Hoxa-11, GHOX1I, Xhoxa11, HOXA11
Epitope
Middle Region
(6), (2), (1), (1), (1), (1)
Reactivity
Rabbit, Rat (Rattus), Mouse (Murine), Cow (Bovine), Dog (Canine), Human
(35), (20), (15), (13), (12), (1), (1)
Host
Rabbit
(25), (13)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(26), (11), (10), (6), (4), (3), (2), (1), (1)
Pubmed 1 reference available
Catalog no. ABIN406665
Quantity 50 µg
Price
289.00 $   Plus shipping costs $45.00
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Immunogen Synthetic peptide directed towards the middle region of human HOXA11
Sequence FETAYGTPENLASSDYPGDKSAEKGPPAATATSAAAAAAA TGAPATSSSD
Predicted Reactivity Bovine : 100 %, Human : 100 %, Rabbit : 100 %, Dog : 90 %, Pig : 80 %
Characteristics This is a rabbit polyclonal antibody against HOXA11. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name HOXA11
Background In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. HOXA11 gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is involved in the regulation of uterine development and is required for female fertility. Mutations in this gene can cause radio-ulnar synostosis with amegakaryocytic thrombocytopenia.In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is involved in the regulation of uterine development and is required for female fertility. Mutations in this gene can cause radio-ulnar synostosis with amegakaryocytic thrombocytopenia.
Molecular Weight 34 kDa
Gene ID 3207
NCBI Accession NM_005523, NP_005514
UniProt P31270
Research Area Chromatin and Nuclear Signaling, Transcription Factors
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 313 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Homeobox A11 (HOXA11) (Middle Region) antibody WB Suggested Anti-HOXA11 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: Transfected 293T
Background publications Connell, Guess, Chen et al.: "HOXA11 is critical for development and maintenance of uterosacral ligaments and deficient in pelvic prolapse." in: The Journal of clinical investigation, Vol. 118, Issue 3, pp. 1050-5, 2008 (PubMed).

Hosts (25), (13)
Reactivities (35), (20), (15), (13), (12), (1), (1)
Applications (26), (11), (10), (6), (4), (3), (2), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (6), (2), (1), (1), (1), (1)
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