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ATG12 Autophagy Related 12 Homolog (S. Cerevisiae) (ATG12) antibody
| Antigen | ATG12 Autophagy Related 12 Homolog (S. Cerevisiae) (ATG12) |
| Synonyms |
APG12, FBR93, APG12L, HAPG12, atg12, CG10861, DmelCG10861, Apg12l, Atg12l, 4931423H11Rik, A330058M13Rik, MGC125080, ATG12, MGC127276, APG12B, AUTOPHAGY 12, AUTOPHAGY 12 B, ATG12A, AUTOPHAGY 12 A, F20D ...
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| Clonality | Polyclonal |
| Host |
 Alternatives Rabbit |
| Reactivity |
Alternatives Human, Mouse (Murine), Rat (Rattus) |
| Application |
Alternatives Western Blotting (WB)
|
| Catalog no. | ABIN411421 |
| Quantity | 100 µg (0.5 mg/ml) |
| Price | 235.00 $ Plus shipping costs $35.00 |
| Shipping to |
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| Availability | Ships within 7 to 10 Business Days |
Additional Information
| Characteristics | 100 ug affinity purified rabbit anti-APG12/ATG12 polyclonal antibody. Reacts with human/mouse/rat. Tested in Western blot. Other applications have not been determined. |
| Alternative name | APG12/ATG12 |
| Gene ID | 67526 |
| Immunogen | Synthetic peptide surrounding amino acid 21 of mouse APG12 |
| Isotype | IgG (Matching secondary antibodies) |
| Description | Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1. ATG12, another member of the autophagy protein family, forms a conjugate with ATG5; this conjugate has a ubiquitin-protein ligase (E3)-like activity for protein lipidation in autophagy. This conjugate also associates with innate immune response proteins such as RIG-I and VISA (also known as IPS-1), inhibiting type I interferon production and permitting viral replication in host cells. ATG12 has also been shown to interact with ATG10 in human embryonic kidney cells in the presence of ATG7. At least two isoforms of ATG12 are known to exist. |
| Synonyms | APG12, FBR93, APG12L, HAPG12, atg12, CG10861, DmelCG10861, Apg12l, Atg12l, 4931423H11Rik, A330058M13Rik, MGC125080, ATG12, MGC127276, APG12B, AUTOPHAGY 12, AUTOPHAGY 12 B, ATG12A, AUTOPHAGY 12 A, F20D21.38, F20D21_38, DKFZp459D2226 |
Application Details
| Application Notes | Western blotting (0.5-4 µg/ml). However, the optimal conditions should be determined individually. |
| Concentration | 0.5 mg/ml |
| Purification | Affinity Purified Antibody |
| Buffer | 0.5 mg/ml affinity purified rabbit anti-APG12 in PBS containing 30% glycerol, 0.5 mg/ml BSA and 0.01% thimerosal. |
| Storage | Store at -20°C. Shelf life: 12 months. The antibody solution should be gently mixed before use. |
| Restrictions | For Research Use only |
Alternatives
Alternatives for antigen "ATG12 Autophagy Related 12 Homolog (S. Cerevisiae) (ATG12)", type "Antibodies"
