TYRO Protein tyrosine Kinase Binding Protein (TYROBP) antibody

Antigen: TYRO Protein tyrosine Kinase Binding Protein (TYROBP)

Synonyms: DAP12, KARAP, PLOSL, TYROBP, Ly83, dap12, Karap, tyrpbp

Clonality: Polyclonal

Host: Rabbit

Reactivity: Rat (Rattus), Mouse (Murine)

Application: Western Blotting (WB)

Catalog no.: ABIN411458

Additional Information

Characteristics: 100 ug affinity purified rabbit anti-DAP12 polyclonal antibody. Reacts with rat and mouse. Tested in Western blotting. Other applications have not been determined. Blocking peptide (Cat.# 5570R-50) is available separately.

Alternative name: DAP12

Gene ID: 22177

Immunogen: Synthetic peptide corresponding to residues surrounding amino acids 94 of mouse DAP-12

Isotype: IgG  (Matching secondary antibodies)

Description: DAP12 (KARAP) is a natural killer (NK) cell-expressed cell surface receptor and belongs to the immunoglobulin and C-type lectin superfamily. Unlike other members of this family which possess immunoreceptor tyrosine-based inhibitory motifs (ITIM), DAP12 contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain and is present as a disulphide-bonded homodimer. Crosslinking of DAP 12-KIR complexes (membrane glycoproteins of the killer-cell inhibitory receptor family without an ITIM in their cytoplasmic domain) results in cellular activation.

Specificity: The antibody can be used for Western blot analysis (0.5-4 μ g/ml). However, the optimal conditions should be determined individually. Blocking peptide (Cat.# 5570RBP-50) is available separately.

Application Details

Application Notes: Western blot analysis (0.5-4 µg/ml). However, the optimal conditions should be determined individually.

Concentration: 0.5 mg/ml

Purification: Affinity Purified Antibody

Buffer: 100 µg (0.5 mg/ml) affinity purified rabbit anti-DAP12 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.

Storage: Store at -20°C. Shelf life: 12 months. The antibody solution should be gently mixed before use.

Research Area: Signaling

Restrictions: For Research Use only