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Characteristics
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100 ug affinity purified rabbit anti-DR3 (also called Asl-1, Apo3, Apo-3, TRAMP, LARD, etc.) polyclonal antibody. Detects 48 kDa DR3 in Western blotting. Reacts with human/mouse/rat. Other species have not been determined. Blockign peptide (Cat.# 3057RBP-50) is available separately.
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Gene ID
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85030
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Immunogen
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Synthetic peptide corresponding to residues surrounding amino acids 378 of mouse DR3
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Isotype
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IgG (Matching secondary antibodies)
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Description
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Apoptosis can be induced by certain cytokines including TNF and Fas in the TNF superfamily through interaction with their death domain (DD) containing receptors, TNFR1 and Fas. A member of the TNF receptor family was recently identified and designated DR3 (also called Wal-1, Apo3, TRAMP and LARD). The ligand for this novel death receptor has been defined as TWEAK (also termed Apo3L). Like TNFR1, overexpression of DR3 triggers apoptosis and NF-kB activation. Activation of DR3 results in recruitment of TRADD (a DD containing adapter molecule). TRADD associates with FADD, TRAF2, and RIP to activate the signaling complex for NF-kB activation. DR3 activates apoptosis through TRADD, FADD, and caspase-8. DR3 is highly expressed in the tissues enriched in lymphocytes including peripheral blood leucocytes (PBL), thymus and spleen.
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Specificity
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The antibody detects a ~48 kDa DR3 in samples from human, mouse, and rat origins.
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