Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21) antibody

Antigen: Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21)

Synonyms: DR6, BM-018, MGC31965, TR7, R74815, AA959878, TNFRSF21, MGC143129, dr6, im:6795346, wu:fa55e01, wu:fb02e11, wu:fc29a09, wu:fi27h08, tnfrsf21, MGC146356

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human, Mouse (Murine), Rat (Rattus)

Application: Western Blotting (WB)

Catalog no.: ABIN411473

Additional Information

Characteristics: 100 ug affinity purified rabbit anti-DR6 (also called TNFR-related death Receptor-6, Death Receptor-6, Death Receptor 6, DR-6, DR 6, etc. ) polyclonal antibody. Detects the 70-80 kDa DR6 in samples of human, mouse, and rat origins. Tested in Western blotting. Other applications have not been determined. Blocking peptide (Cat.# 3216RBP-50) is available separately.

Alternative name: DR6

Gene ID: 94185

Immunogen: Synthetic peptide surrounding amino acid 622 of rat DR6

Isotype: IgG  (Matching secondary antibodies)

Description: Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several novel death receptor including DR3, DR4, and DR5 were recently identified. A new death domain containing receptor in the TNFR family was cloned recently and termed DR6 for death receptor 6. Like TNF-R1, DR6 interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-kB and JNK. DR6 is widely expressed in human tissues and cell lines.

Specificity: The antibody detects ~68 kDa of DR6 in samples from human, mouse and rat origins. Reactivity to other species has not been determined.

Application Details

Application Notes: Western blotting (0.5-4 µg/ml). However, the optimal conditions should be determined individually. The antibody detects ~68 kDa of DR6 in samples from human, mouse and rat origins.

Concentration: 0.5 mg/ml

Purification: Affinity Purified Antibody

Buffer: 100 µg (0.5 mg/ml) antigen affinity purified rabbit anti-DR6 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol and 0.01% Thimerosal.

Storage: Store at -20°C. Shelf life: 12 months. The antibody solution should be gently mixed before use.

Research Area: Apoptosis/Necrosis, Death Receptors, Signaling

Restrictions: For Research Use only