Noggin (NOG) antibody

Antigen: Noggin (NOG)

Synonyms: SYM1, SYNS1, nog-A, NOG, noggin

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Western Blotting (WB)

Catalog no.: ABIN411547

Additional Information

Characteristics: 100 ug affinity purified rabbit anti-human Noggin polyclonal antibody. Perform well in Western blot. Other applications have not been determined.

Alternative name: Noggin

Gene ID:  1117817

Immunogen: E. coli expressed recombinant human Noggin

Isotype: IgG  (Matching secondary antibodies)

Description: Noggin belongs to a group of diffusible proteins which bind to ligands of the TGF-beta family and regulate their activity by inhibiting their access to signaling receptors. Noggin was originally identified as a BMP-4 antagonist whose action is critical for proper formation of the head and other dorsal structures. Consequently, Noggin has been shown to modulate the activities of other BMPs including BMP-2,-7,-13, and -14. Targeted deletion of Noggin in mice results in prenatal death and recessive phenotype displaying a severely malformed skeletal system. Conversely, transgenic mice over-expressing Noggin in mature osteoblasts display impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis.

Application Details

Application Notes: Western blotting (0.5-4 µg/ml). However, the optimal concentrations should be determined individually. Recombinant human Noggin (Cat.# 4675-20) can be used as a positive control.

Concentration: 0.5 mg/ml

Purification: Affinity Purified Antibody

Buffer: 100 µg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.

Storage: Store at -20°C. Shelf life: 12 months. The antibody solution should be gently mixed before use.

Research Area: Embryogenesis, Lineage Markers

Restrictions: For Research Use only