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Antibodies
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anti-Signal Transducer and Activator of Transcription 2 (STAT2) antibody
Signal Transducer and Activator of Transcription 2 (STAT2) antibody
| Antigen |
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| Synonyms |
P113, ISGF-3, STAT113, MGC59816, STAT2, p113, isgf-3, stat113 |
| Clonality |
Polyclonal |
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Host
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Reactivity
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Application
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Western Blotting (WB) (36), Immunofluorescence (IF) (20), Flow Cytometry (FACS) (18), Immunohistochemistry (IHC) (11), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (10), ELISA (7), Enzyme Immunoassay (EIA) (6), Immunoprecipitation (IP) (6), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (2), Immunoelectron Microscopy (IEM) (1), Immunohistochemistry (Frozen Sections) (IHC (fro)) (1)
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| Catalog no. |
ABIN411595 |
| Quantity |
100 µg (0.5 mg/ml) |
| Price |
225.00 $ Plus shipping costs $35.00
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| Shipping to |
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| Availability |
Ships within 7 to 10 Business Days |
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Characteristics
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100 ug affinity purified rabbit anti-Stat2 polyclonal antibody. Detects ~110 kDa Stat2 in samples of human/mouse/rat origins. Tested in Western blot. Other applications have not been determined. Blocking peptide (Cat.# 3468BP-50) is available separately.
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Alternative name
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Stat2
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Gene ID
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6773
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Immunogen
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Synthetic peptide surrounding amino acid 615 of rat Stat2
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Isotype
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IgG (Matching secondary antibodies)
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Description
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Membrane receptor signaling by various ligands induces activation of Jak kinases which then leads to tyrosine phosphorylation of the various Stat transcription factors. Stat1 and Stat2 are induced by IFN-α and form a heterodimer which is part of the ISGF3 transcription factor complex. Although early reports indicate Stat3 activation by EGF and IL-6, it has been shown that Stat3β appears to be activated by both while Stat3α is activated by EGF, but not by IL-6. Highest expression of Stat4 is seen in testis and myeloid cells. IL-12 has been identified as an activator of Stat4. Stat5 is activated by prolactin and by IL-3. Stat6 is involved in IL-4 activated signaling pathways.
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Specificity
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The antibody recognizes ~113 kDa of Stat2 from samples of human, mouse and rat origins. Reactivity to other species has not been determined.
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Application Notes
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Western blotting (0.5-4 µg/ml), However, the optimal concentrations should be determined individually. The antibody recognizes ~113 kDa of Stat2 from samples of human, mouse and rat origins. Reactivity to other species has not been determined.
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Concentration
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0.5 mg/ml
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Purification
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Affinity Purified Antibody
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Buffer
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100 µg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.
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Storage
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Store at -20°C. Shelf life: 12 months. The antibody solution should be gently mixed before use.
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Research Area
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Chromatin and Nuclear Signaling, Transcription Factors, Signaling, Receptors, Inflammation
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Restrictions
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For Research Use only
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Alternatives for antigen "Signal Transducer and Activator of Transcription 2 (STAT2)", type "Antibodies"
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Hosts
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Rabbit (52), Mouse (3)
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Reactivities
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Human (52), Rat (Rattus) (21), Mouse (Murine) (20), Cow (Bovine) (3), Pig (Porcine) (2), Chicken (1), Dog (Canine) (1)
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Applications
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Western Blotting (WB) (36), Immunofluorescence (IF) (20), Flow Cytometry (FACS) (18), Immunohistochemistry (IHC) (11), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (10), ELISA (7), Enzyme Immunoassay (EIA) (6), Immunoprecipitation (IP) (6), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (2), Immunoelectron Microscopy (IEM) (1), Immunohistochemistry (Frozen Sections) (IHC (fro)) (1)
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Conjugates
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Alexa Flour 488 (1), Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1), RBITC (1)
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Epitopes
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C-Term (2), pTyr689 (1), pTyr690 (1), pY690 (1)
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Alternatives 
