Microtubule-Associated Protein tau (MAPT) antibody

Antigen: Microtubule-Associated Protein tau (MAPT)

Synonyms: TAU, MSTD, PPND, DDPAC, MAPTL, MTBT1, MTBT2, FTDP-17, FLJ31424, MGC138549, Tau, Mtapt, AI413597, AW045860, pTau, RNPTAU, MGC156663, tau, MGC134287, xtp, MAPT

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human, Mouse (Murine), Rat (Rattus), Chicken, Cow (Bovine)

Application: Western Blotting (WB)

Catalog no.: ABIN411601

Additional Information

Characteristics: 100 ug affinity purified rabbit anti-Tau polyclonal antibody. Reacts with human/mouse/rat/chicken/bovine. Tested in Western blot analysis. Other applications have not been determined. Blocking peptide (3549RBP-50) is available separately.

Alternative name: Tau

Gene ID: 29477

Immunogen: Synthetic peptide surrounding amino acid 395 of rat Tau

Isotype: IgG  (Matching secondary antibodies)

Description: Tau, a microtubule-binding protein which serves to stabilize microtubules in growing axons, is found to be hyperphosphorylated in paired helical filaments (PHF), the major fibrous component of neurofibrillary lesions associated with Alzheimer’s disease. Hyperphosphorylation of Tau is thought to be the critical event leading to the assembly of PHF. Six Tau protein isoforms have been identified, all of which are phosphorylated by GSK3. This presents the possibility that miscues in GSK3 signaling contribute to the onset of Alzheimer’s disease.

Application Details

Application Notes: Western blotting (0.5-4 µg/ml). However, the optimal conditions should be determined individually. Other applications have not been determined. The antibody recognizes mainly the truncated Tau (~30 kDa) in sample from human, mouse and rat origins. Other isoforms of Tau at 35 kDa, 60 kDa and 80 kDa can also be recognized. Reactivity to other species has not been tested.

Concentration: 0.5 mg/ml

Purification: Affinity Purified Antibody

Buffer: 100 µg (0.5 mg/ml) affinity purified rabbit anti-TAU polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.

Storage: Store at -20°C. Shelf life: 12 months. The antibody solution should be gently mixed before use.

Research Area: Neurology, Cytoskeleton, Alzheimer's Disease, Alzheimer's Disease

Restrictions: For Research Use only