TGF-Beta3 antibody
| Antigen |
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| Clonality |
Polyclonal |
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Host
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Reactivity
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Application
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| Catalog no. |
ABIN411606 |
| Quantity |
100 µg (0.5 mg/ml) |
| Price |
225.00 $ Plus shipping costs $35.00
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| Shipping to |
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| Availability |
Ships within 7 to 10 Business Days |
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Characteristics
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100 ug affinity purified rabbit anti-human/mouse/rat TGF-beta3 polyclonal antibody. Tested in Western blot analysis.
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Gene ID
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7043
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Immunogen
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Synthetic peptide surrounding amino acid 254of human TGF-β3
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Isotype
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IgG (Matching secondary antibodies)
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Description
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The three mammalian isoforms of TGF-beta (TGF-beta1, TGF-beta2, TGF-beta3) signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes including embryogenesis, tissue remodeling and would healing. They are secreted predominantly as latent complexes which are stored at the cell surface and in the extracellular matrix. The release of biologically active TGF-beta isoform from a latent complex involves proteolytic processing of the complex and/or induction of conformational changes by proteins such as thrombospondin-1. TGF-beta2 has been shown to exert suppressive effects on IL-2 dependent T-cell growth, and may also have an autocrine function in enhancing tumor growth by suppressing immuno-surveillance of tumor development.
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Specificity
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The antibody recognizes~25 kDa TGF- β 3 from samples of human, mouse, and rat origins. Reactivity to other species has not been tested.
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Application Notes
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Western blotting (0.5-4 µg/ml). However, the optimal concentrations should be determined individually. The antibody recognizes~25 kDa TGF-β3 from samples of human, mouse, and rat origins. Reactivity to other species has not been tested.
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Concentration
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0.5 mg/ml
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Purification
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Affinity Purified Antibody
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Buffer
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100 µg (0.5 mg/ml) peptide affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.
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Storage
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Store at -20°C. Shelf life: 12 months. The antibody solution should be gently mixed before use.
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Research Area
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Growth Factors, Signaling
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Restrictions
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For Research Use only
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Alternatives for antigen "TGF-Beta3", type "Antibodies"
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Hosts
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Rabbit (25)
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Reactivities
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Human (23), Mouse (Murine) (21), Rat (Rattus) (21), Rabbit (17), Dog (Canine) (15), Cow (Bovine) (2), Pig (Porcine) (2), Chicken (1), Horse (Equine) (1)
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Applications
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Flow Cytometry (FACS) (18), Immunofluorescence (IF) (18), Western Blotting (WB) (8), ELISA (4), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (2), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (2), Immunoprecipitation (IP) (2), Immunoelectron Microscopy (IEM) (1), Immunohistochemistry (IHC) (1)
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Conjugates
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Alexa Flour 488 (1), Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1), RBITC (1)
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Alternatives 
