TNF Receptor-Associated Factor 6 (TRAF6) antibody

Antigen: TNF Receptor-Associated Factor 6 (TRAF6)

Synonyms: RNF85, MGC:3310, AI851288, 2310003F17Rik, C630032O20Rik, LOC716907, xtraf6, traf6-B, MGC81955, DTRAF2, TRAF, TRAF2, TRAF6, dTRAF6, DmelCG10961, CG10961, rnf85, MGC79673, MGC128039, GB10539, fi15f02, MGC63704, zgc:63704, wu:fi15f02, traf6

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human, Mouse (Murine), Rat (Rattus)

Application: Western Blotting (WB)

Catalog no.: ABIN411617

Additional Information

Characteristics: 100 ug affinity purified rabbit anti-TRAF6 polyclonal antibody. Reacts with human, mouse and rat. Detects ~54 kDa TRAF6 in Western blot analysis. Blocking peptide (Cat.# 3566RBP-50) is available separately.

Alternative name: TRAF6

Gene ID: 311245

Immunogen: Synthetic peptide surrounding amino acid 436 of rat TRAF6

Isotype: IgG  (Matching secondary antibodies)

Description: TRAFs (TNF receptor associated proteins) form a family of cytoplasmic adapter proteins that mediate signal transduction from many members of the TNF-receptor superfamily and the interleukin-1 receptor. The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization. Recent molecular cloning studies have lead to identification of six TRAFs (TRAF1-TRAF6). Recently it has been shown that TRANCE/OPGL activates the antiapoptotic serine/threonine kinase Akt/PKB through a signaling complex involving c-Src and TRAF6. Mice deficient in TRAF6 are osteopetrotic with defects in bone remodeling and tooth eruption due to impaired osteoclast function. Like TRAF2 and TRAF3, TRAF6 is also essential for perinatal and postnatal survival. These findings establish diverse and critical roles for TRAF6 in perinatal and postnatal survival, bone metabolism, LPS, and cytokine signaling.

Specificity: The antibody recognizes 54 kDa TRAF6 in samples of human and mouse origins. Reactivity to other species has not been tested.

Synonyms: RNF85, MGC:3310, AI851288, 2310003F17Rik, C630032O20Rik, LOC716907, xtraf6, traf6-B, MGC81955, DTRAF2, TRAF, TRAF2, TRAF6, dTRAF6, DmelCG10961, CG10961, rnf85, MGC79673, MGC128039, GB10539, fi15f02, MGC63704, zgc:63704, wu:fi15f02, traf6

Application Details

Application Notes: Western blotting (0.5-4 µg/ml). However, the optimal concentrations should be determined individually. The antibody recognizes 54 kDa TRAF6 in samples of human and mouse origins. Reactivity to other species has not been tested.

Concentration: 0.5 mg/ml

Purification: Affinity Purified Antibody

Buffer: 100 µg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.

Storage: Store at -20°C. Shelf life: 12 months. The antibody solution should be gently mixed before use.

Restrictions: For Research Use only