TNFRSF10B antibody (Tumor Necrosis Factor Receptor Superfamily, Member 10b)

Details for Product anti-TNFRSF10B Antibody No. ABIN4361766, Supplier: Log in to see
Antigen
  • TNFRSF10B
  • dr5
  • cd262
  • killer
  • trick2
  • trickb
  • xDR-M1
  • xDR-M2
  • ztnfr9
  • trailr2
  • trick2a
  • trick2b
  • CD262
  • DR5
  • KILLER
  • KILLER/DR5
  • TRAIL-R2
  • TRAILR2
  • TRICK2
  • TRICK2A
  • TRICK2B
  • TRICKB
  • ZTNFR9
  • Ly98
  • MK
  • tumor necrosis factor receptor superfamily, member 10b
  • Tnfrsf10b
  • TNFRSF10B
  • tnfrsf10b-b
  • tnfrsf10b
Alternatives
anti-Human TNFRSF10B antibody for Flow Cytometry
Reactivity
Human
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76
26
1
1
1
1
1
Host
Rabbit
180
169
10
6
6
2
Clonality
Polyclonal
Conjugate
This TNFRSF10B antibody is un-conjugated
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20
16
6
5
5
5
4
4
4
4
4
4
4
4
3
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
Application
Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
194
162
73
51
38
31
27
26
14
13
13
4
4
4
3
3
2
1
Options
Supplier
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Supplier Product No.
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Immunogen Rabbit anti-DR5 polyclonal antibody was raised against a peptide corresponding to amino acids 388 to 407 (isoform 2) of human DR5 precursor (1,2). The same sequence is found in isoform 1 at amino acids 417-436.
Purification Protein G purified
Alternative Name TRAIL R2/TNFRSF10B (TNFRSF10B Antibody Abstract)
Background Gene Symbol: TNFRSF10B
Gene ID 8795
Pathways p53 Signaling, Apoptosis, Positive Regulation of Endopeptidase Activity
Application Notes Western Blot 5 μg/mL, Flow Cytometry 1:20-1:2000, Immunohistochemistry, Immunocytochemistry/Immunofluorescence 1:10-1:500, Immunohistochemistry-Paraffin 1:10-1:500Flow Cytometry (Cell Surface): As reported in KOYAMA (2003) Immunocytochemistry/Immunofluorescence: As reported in Georgakis et al. (2005) Immunohistochemistry (paraffin): As reported in Younes et al. (2006). Use in Immunohistochemistry reported in scientific literature (PMID 27740879).
Comment

The antibodies are intended for use in vitro experiments only. Our antibodies have not been tested nor are recommended for use in vivo.

Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS
Buffer contains: 0.05 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C,-20 °C
Storage Comment Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Supplier Images
Immunofluorescence (IF) image for anti-Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) antibody (ABIN4361766) Immunocytochemistry/Immunofluorescence: TRAIL R2/TNFRSF10B Antibody - HepG2 cells we...
Western Blotting (WB) image for anti-Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) antibody (ABIN4361766) Western Blot: TRAIL R2/TNFRSF10B Antibody - Total protein from HL-60, HepG2, HCT-116...
Product cited in: Shin, Kang, Lee, Kim: "Hepatitis B virus-triggered autophagy targets TNFRSF10B/death receptor 5 for degradation to limit TNFSF10/TRAIL response." in: Autophagy, Vol. 12, Issue 12, pp. 2451-2466, 2016 (PubMed).

Xu, Zhou, Xu, Kho, Zhuang, Raz, Wu: "The role of Cullin3-mediated ubiquitination of the catalytic subunit of PP2A in TRAIL signaling." in: Cell cycle (Georgetown, Tex.), Vol. 13, Issue 23, pp. 3750-8, 2015 (PubMed). (Sample species: Human). Further details: Western Blotting

Prabhu, Allen, Dicker, El-Deiry: "Small-Molecule ONC201/TIC10 Targets Chemotherapy-Resistant Colorectal Cancer Stem-like Cells in an Akt/Foxo3a/TRAIL-Dependent Manner." in: Cancer research, Vol. 75, Issue 7, pp. 1423-32, 2015 (PubMed). (Sample species: Human). Further details: Flow Cytometry

Talekar, Allen, Dicker, El-Deiry: "ONC201 induces cell death in pediatric non-Hodgkin's lymphoma cells." in: Cell cycle (Georgetown, Tex.), Vol. 14, Issue 15, pp. 2422-8, 2015 (PubMed). Further details: Flow Cytometry

Liu, Hawkins, Vilgelm, Pawlikowski, Ecsedy, Sosman, Kelley, Richmond: "Combining an Aurora Kinase Inhibitor and a Death Receptor Ligand/Agonist Antibody Triggers Apoptosis in Melanoma Cells and Prevents Tumor Growth in Preclinical Mouse Models." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 21, Issue 23, pp. 5338-48, 2015 (PubMed). (Sample species: Human). Further details: Western Blotting

Allen, Crowder, Crowder, El-Deiry: "First-In-Class Small Molecule ONC201 Induces DR5 and Cell Death in Tumor but Not Normal Cells to Provide a Wide Therapeutic Index as an Anti-Cancer Agent." in: PLoS ONE, Vol. 10, Issue 11, pp. e0143082, 2015 (PubMed). (Sample species: Human). Further details: Flow Cytometry

Foster, Jane, Premkumar, Morales, Pollack: "NVP-BKM120 potentiates apoptosis in tumor necrosis factor-related apoptosis-inducing ligand-resistant glioma cell lines via upregulation of Noxa and death receptor 5." in: International journal of oncology, Vol. 47, Issue 2, pp. 506-16, 2015 (PubMed). (Sample species: Human). Further details: Immunocytochemistry,Immunofluorescence

Chen, Bozza, Di, Zhang, Hallett, Zhang: "H-Ras regulation of TRAIL death receptor mediated apoptosis." in: Oncotarget, Vol. 5, Issue 13, pp. 5125-37, 2014 (PubMed). (Sample species: Human).

Xu, Xu, Zhou, Zhuang, Wang, Boerner, Wu: "Regulation of the Src-PP2A interaction in tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-induced apoptosis." in: The Journal of biological chemistry, Vol. 288, Issue 46, pp. 33263-71, 2013 (PubMed). (Sample species: Human). Further details: Western Blotting

Di, Zhang, Zhang, Takeda, Rivera Rosado, Zhang: "Accumulation of autophagosomes in breast cancer cells induces TRAIL resistance through downregulation of surface expression of death receptors 4 and 5." in: Oncotarget, Vol. 4, Issue 9, pp. 1349-64, 2013 (PubMed). Further details: Immunocytochemistry,Immunofluorescence

Abdulghani, Allen, Dicker, Liu, Goldenberg, Smith, Humphreys, El-Deiry: "Sorafenib sensitizes solid tumors to Apo2L/TRAIL and Apo2L/TRAIL receptor agonist antibodies by the Jak2-Stat3-Mcl1 axis." in: PLoS ONE, Vol. 8, Issue 9, pp. e75414, 2013 (PubMed). (Sample species: Human). Further details: Flow Cytometry

Qiu, Hu, Tang, Liu, Zhuang, Yang, Hua: "Annexin V-TRAIL fusion protein is a more sensitive and potent apoptotic inducer for cancer therapy." in: Scientific reports, Vol. 3, pp. 3565, 2013 (PubMed). (Sample species: Human). Further details: Western Blotting

Allen, Ferrini, Dicker, Batzer, Chen, Oltean, Lin, Renshaw, Kretz-Rommel, El-Deiry: "Targeting TRAIL death receptor 4 with trivalent DR4 Atrimer complexes." in: Molecular cancer therapeutics, Vol. 11, Issue 10, pp. 2087-95, 2012 (PubMed). Further details: Cell Sorting

Jane, Premkumar, Pollack: "Bortezomib sensitizes malignant human glioma cells to TRAIL, mediated by inhibition of the NF-{kappa}B signaling pathway." in: Molecular cancer therapeutics, Vol. 10, Issue 1, pp. 198-208, 2011 (PubMed). Further details: Western Blotting

Zhang, Chen, De Paiva, Corrales, Volpe, McClellan, Farley, Li, Pflugfelder: "Interferon-? exacerbates dry eye-induced apoptosis in conjunctiva through dual apoptotic pathways." in: Investigative ophthalmology & visual science, Vol. 52, Issue 9, pp. 6279-85, 2011 (PubMed). (Sample species: Mouse (Murine)). Further details: Immunocytochemistry,Immunofluorescence,Immunohistochemistry

Wang, Ren, Liu, Lahat, Torres, Lopez, Lazar, Hayes-Jordan, Liu, Bankson, Hazle, Lev: "TRAIL and doxorubicin combination induces proapoptotic and antiangiogenic effects in soft tissue sarcoma in vivo." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 16, Issue 9, pp. 2591-604, 2010 (PubMed). (Sample species: Human). Further details: Immunohistochemistry (Paraffin-embedded Sections)

Xu, Zhou, Wei, Philipsen, Wu: "Sp1-mediated TRAIL induction in chemosensitization." in: Cancer research, Vol. 68, Issue 16, pp. 6718-26, 2008 (PubMed). (Sample species: Human). Further details: Western Blotting

Kusaba, Nakao, Goto, Nishimura, Kawashimo, Shibata, Motoyoshi, Taura, Ichikawa, Hamasaki, Eguchi: "Abrogation of constitutive STAT3 activity sensitizes human hepatoma cells to TRAIL-mediated apoptosis." in: Journal of hepatology, Vol. 47, Issue 4, pp. 546-55, 2007 (PubMed).

Abdelrahim, Newman, Vanderlaag, Samudio, Safe: "3,3'-diindolylmethane (DIM) and its derivatives induce apoptosis in pancreatic cancer cells through endoplasmic reticulum stress-dependent upregulation of DR5." in: Carcinogenesis, Vol. 27, Issue 4, pp. 717-28, 2006 (PubMed). Further details: Western Blotting

Younes, Georgakis, Rahmani, Beer, Younes: "Functional expression of TRAIL receptors TRAIL-R1 and TRAIL-R2 in esophageal adenocarcinoma." in: European journal of cancer (Oxford, England : 1990), Vol. 42, Issue 4, pp. 542-7, 2006 (PubMed). Further details: Western Blotting,Immunohistochemistry (Paraffin-embedded Sections),Cell Sorting

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