TNFRSF10B antibody (Tumor Necrosis Factor Receptor Superfamily, Member 10b)

Details for Product anti-TNFRSF10B Antibody No. ABIN4361767, Supplier: Log in to see
Antigen
  • TNFRSF10B
  • dr5
  • cd262
  • killer
  • trick2
  • trickb
  • xDR-M1
  • xDR-M2
  • ztnfr9
  • trailr2
  • trick2a
  • trick2b
  • CD262
  • DR5
  • KILLER
  • KILLER/DR5
  • TRAIL-R2
  • TRAILR2
  • TRICK2
  • TRICK2A
  • TRICK2B
  • TRICKB
  • ZTNFR9
  • Ly98
  • MK
  • tumor necrosis factor receptor superfamily, member 10b
  • Tnfrsf10b
  • TNFRSF10B
  • tnfrsf10b-b
  • tnfrsf10b
Alternatives
anti-Human TNFRSF10B antibody for Flow Cytometry
Reactivity
Human
324
76
26
1
1
1
1
1
Host
Rabbit
180
169
10
6
6
2
Clonality
Polyclonal
Conjugate
This TNFRSF10B antibody is un-conjugated
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20
16
6
5
5
5
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4
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4
4
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2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
Application
Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
194
162
73
51
38
31
27
26
14
13
13
4
4
4
3
3
2
1
Options
Supplier
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Supplier Product No.
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Immunogen Rabbit anti-DR5 polyclonal antibody was raised against a peptide corresponding to amino acids 388 to 407 (isoform 2) of human DR5 precursor (1,2). The same sequence is found in isoform 1 at amino acids 417-436.
Purification Protein G purified
Alternative Name TRAIL R2/TNFRSF10B (TNFRSF10B Antibody Abstract)
Background Gene Symbol: TNFRSF10B
Gene ID 8795
Pathways p53 Signaling, Apoptosis, Positive Regulation of Endopeptidase Activity
Application Notes Western Blot 5 μg/mL, Flow Cytometry 1 μL/1 million cells, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-ParaffinFlow cytometry/ FACS analysis, Immunohistochemistry-paraffin, Immunofluorescence, Western Blot and Immunocytochemistry
Comment

The antibodies are intended for use in vitro experiments only. Our antibodies have not been tested nor are recommended for use in vivo.

Restrictions For Research Use only
Format Liquid
Buffer PBS
Buffer contains: No Preservative
Preservative Without preservative
Storage -20 °C
Storage Comment Store at -20°C. Avoid freeze-thaw cycles.
Product cited in: Wang, Ren, Liu, Lahat, Torres, Lopez, Lazar, Hayes-Jordan, Liu, Bankson, Hazle, Lev: "TRAIL and doxorubicin combination induces proapoptotic and antiangiogenic effects in soft tissue sarcoma in vivo." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 16, Issue 9, pp. 2591-604, 2010 (PubMed). (Sample species: Human). Further details: Immunohistochemistry (Paraffin-embedded Sections)

Abdelrahim, Newman, Vanderlaag, Samudio, Safe: "3,3'-diindolylmethane (DIM) and its derivatives induce apoptosis in pancreatic cancer cells through endoplasmic reticulum stress-dependent upregulation of DR5." in: Carcinogenesis, Vol. 27, Issue 4, pp. 717-28, 2006 (PubMed). Further details: Western Blotting

Younes, Georgakis, Rahmani, Beer, Younes: "Functional expression of TRAIL receptors TRAIL-R1 and TRAIL-R2 in esophageal adenocarcinoma." in: European journal of cancer (Oxford, England : 1990), Vol. 42, Issue 4, pp. 542-7, 2006 (PubMed). Further details: Western Blotting,Immunohistochemistry (Paraffin-embedded Sections),Cell Sorting

Georgakis, Li, Humphreys, Andreeff, OBrien, Younes, Carbone, Albert, Younes et al.: "Activity of selective fully human agonistic antibodies to the TRAIL death receptors TRAIL-R1 and TRAIL-R2 in primary and cultured lymphoma cells: induction of apoptosis and enhancement of ..." in: British journal of haematology, Vol. 130, Issue 4, pp. 501-10, 2005 (PubMed). Further details: Immunocytochemistry,Immunofluorescence

Kim, Nakagawa, Fei, Rustgi, El-Deiry: "Targeting Bcl-xL in esophageal squamous cancer to sensitize to chemotherapy plus TRAIL-induced apoptosis while normal epithelial cells are protected by blockade of caspase 9." in: Cell death and differentiation, Vol. 11, Issue 5, pp. 583-7, 2004 (PubMed).

Dandrea, Hellmold, Jonsson, Zhivotovsky, Hofer, Wärngård, Cotgreave: "The transcriptosomal response of human A549 lung cells to a hydrogen peroxide-generating system: relationship to DNA damage, cell cycle arrest, and caspase activation." in: Free radical biology & medicine, Vol. 36, Issue 7, pp. 881-96, 2004 (PubMed).

Jin, McDonald, Dicker, El-Deiry: "Deficient tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor transport to the cell surface in human colon cancer cells selected for resistance to TRAIL-induced apoptosis." in: The Journal of biological chemistry, Vol. 279, Issue 34, pp. 35829-39, 2004 (PubMed).

Fan, Zou, Song, Wei: "Synergistic antitumor activity of TRAIL combined with chemotherapeutic agents in A549 cell lines in vitro and in vivo." in: Cancer chemotherapy and pharmacology, Vol. 55, Issue 2, pp. 189-96, 2004 (PubMed).

Zou, Liu, Yue, Zhou, Sporn, Lotan, Khuri, Sun et al.: "c-Jun NH2-terminal kinase-mediated up-regulation of death receptor 5 contributes to induction of apoptosis by the novel synthetic triterpenoid methyl-2-cyano-3,12-dioxooleana-1, 9-dien-28-oate in ..." in: Cancer research, Vol. 64, Issue 20, pp. 7570-8, 2004 (PubMed).

Kandasamy, Srinivasula, Alnemri, Thompson, Korsmeyer, Bryant, Srivastava et al.: "Involvement of proapoptotic molecules Bax and Bak in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced mitochondrial disruption and apoptosis: differential regulation of ..." in: Cancer research, Vol. 63, Issue 7, pp. 1712-21, 2003 (PubMed).

Koyama et al.: "Flow cytometric measurement of tumor necrosis factor-related apoptosis-inducing ligand and its receptors in gastric epithelium and infiltrating mucosal lymphocytes in Helicobacter pylori-associated ..." in: Journal of gastroenterology and hepatology, Vol. 18, Issue 7, pp. 763-70, 2003 (PubMed). Further details: Flow Cytometry

Koyama, Koike, Adachi: "Expression of TNF-related apoptosis-inducing ligand (TRAIL) and its receptors in gastric carcinoma and tumor-infiltrating lymphocytes: a possible mechanism of immune evasion of the tumor." in: Journal of cancer research and clinical oncology, Vol. 128, Issue 2, pp. 73-9, 2002 (PubMed).

Zhang, Xie, Xu, Yang, Xu, Sun, Wang, Curiel, Hsu, Mountz: "Hepatic DR5 induces apoptosis and limits adenovirus gene therapy product expression in the liver." in: Journal of virology, Vol. 76, Issue 11, pp. 5692-700, 2002 (PubMed).

Eid, Lewis, Kumar: "Mifepristone pretreatment overcomes resistance of prostate cancer cells to tumor necrosis factor alpha-related apoptosis-inducing ligand (TRAIL)." in: Molecular cancer therapeutics, Vol. 1, Issue 10, pp. 831-40, 2002 (PubMed).

Cuello, Ettenberg, Clark, Keane, Posner, Nau, Dennis, Lipkowitz et al.: "Down-regulation of the erbB-2 receptor by trastuzumab (herceptin) enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in breast and ovarian cancer cell lines that ..." in: Cancer research, Vol. 61, Issue 12, pp. 4892-900, 2001 (PubMed).

Basile, Zacny, Münger et al.: "The cytokines tumor necrosis factor-alpha (TNF-alpha ) and TNF-related apoptosis-inducing ligand differentially modulate proliferation and apoptotic pathways in human keratinocytes expressing the ..." in: The Journal of biological chemistry, Vol. 276, Issue 25, pp. 22522-8, 2001 (PubMed).

Burns, Bernhard, El-Deiry: "Tissue specific expression of p53 target genes suggests a key role for KILLER/DR5 in p53-dependent apoptosis in vivo." in: Oncogene, Vol. 20, Issue 34, pp. 4601-12, 2001 (PubMed).

Kim, Fisher, Xu, el-Deiry: "Molecular determinants of response to TRAIL in killing of normal and cancer cells." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 6, Issue 2, pp. 335-46, 2000 (PubMed).

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