Keratin 19 (KRT19) (AA 311-335) antibody

Details for Product No. ABIN452456
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Antigen
Epitope
AA 311-335
(40), (11), (10), (7), (6), (6), (6), (5), (4), (4), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(301), (58), (51), (17), (17), (16), (13), (5), (4), (3), (2), (1), (1), (1)
Host
Mouse
(176), (135), (4), (4), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(12), (5), (4), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(235), (141), (128), (92), (67), (57), (54), (29), (18), (10), (4), (4), (1)
Pubmed 14 references available
Quantity 5 mL
Shipping to United States (Change)
Availability Discontinued
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Catalog No. ABIN452456
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Immunogen Keratin K19 of Mr 40 000, from cultured human MCF-7 cells
Clone A53-B-A2 (Ks 19-1)
Isotype IgG2a
Characteristics Synonyms: Cytokeratin-19, Keratin-19, KRT19, CK19, K19, Keratin type I cytoskeletal 19
Purification Affinity Purified
Alternative Name Cytokeratin 19
Background Cytokeratin 19 is a member of the keratin family. The keratins are intermediate filamentproteins responsible for the structural integrity of epithelial cells and are subdivided intocytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which arearranged in pairs of heterotypic keratin chains. Unlike its related family members, thissmallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopesthe developing epidermis. Keratin 19 is not expressed in hepatocytes, therefore, antibodyto keratin 19 is useful in the identification of liver metastasis. The degree of keratin 19positivity in breast cancer distinguishes malignant from benign tumours. Keratin 19 is oftenco-expressed with keratin 7.
Gene ID 3880
UniProt P08727
Research Area Signaling, Cytoskeleton, Cytokeratins, Extracellular Matrix
Application Notes Immunoblotting. Immunofluorescence microscopy. Immunohistochemistry on frozen and paraffin sections: Ready-to-use. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8°C. DO NOT FREEZE! Shelf life: one year from despatch.
Expiry Date 12 months
Background publications Karsten, Papsdorf, Roloff et al.: "Monoclonal anti-cytokeratin antibody from a hybridoma clone generated by electrofusion." in: European journal of cancer & clinical oncology, Vol. 21, Issue 6, pp. 733-40, 1985 (PubMed).

Dockhorn-Dworniczak, Franke, Schröder et al.: "Patterns of expression of cytoskeletal proteins in human thyroid gland and thyroid carcinomas." in: Differentiation; research in biological diversity, Vol. 35, Issue 1, pp. 53-71, 1988 (PubMed).

Kasper, Stosiek, Typlt et al.: "Histological evaluation of three new monoclonal anti-cytokeratin antibodies. 1. Normal tissues." in: European journal of cancer & clinical oncology, Vol. 23, Issue 2, pp. 137-47, 1988 (PubMed).

Lindberg, Rheinwald: "Suprabasal 40 kd keratin (K19) expression as an immunohistologic marker of premalignancy in oral epithelium." in: The American journal of pathology, Vol. 134, Issue 1, pp. 89-98, 1989 (PubMed).

Walker: "Breast myoepithelium--the ignored cell." in: The Journal of pathology, Vol. 156, Issue 1, pp. 5-6, 1988 (PubMed).

Moll, Franke, Schiller et al.: "The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells." in: Cell, Vol. 31, Issue 1, pp. 11-24, 1983 (PubMed).

van der Gaast, Schoenmakers, Kok et al.: "Evaluation of a new tumour marker in patients with non-small-cell lung cancer: Cyfra 21.1." in: British journal of cancer, Vol. 69, Issue 3, pp. 525-8, 1994 (PubMed).

Sugama, Kitamura, Kawai et al.: "Clinical usefulness of CYFRA assay in diagnosing lung cancer: measurement of serum cytokeratin fragment." in: Japanese journal of cancer research : Gann, Vol. 85, Issue 11, pp. 1178-84, 1995 (PubMed).

Stieber, Hasholzner, Bodenmüller et al.: "CYFRA 21-1. A new marker in lung cancer." in: Cancer, Vol. 72, Issue 3, pp. 707-13, 1993 (PubMed).

Petersen, Song, Hügle-Dörr et al.: "Mapping of linear epitopes recognized by monoclonal antibodies with gene-fragment phage display libraries." in: Molecular & general genetics : MGG, Vol. 249, Issue 4, pp. 425-31, 1996 (PubMed).

Demirkesen, Hoede, Moll: "Epithelial markers and differentiation in adnexal neoplasms of the skin: an immunohistochemical study including individual cytokeratins." in: Journal of cutaneous pathology, Vol. 22, Issue 6, pp. 518-35, 1996 (PubMed).

Dittadi, Barioli, Gion et al.: "Standardization of assay for cytokeratin-related tumor marker CYFRA21.1 in urine samples." in: Clinical chemistry, Vol. 42, Issue 10, pp. 1634-8, 1996 (PubMed).

Höchtlen-Vollmar, Gruber, Bodenmüller et al.: "Occult epithelial tumor cells detected in bone marrow by an enzyme immunoassay specific for cytokeratin 19." in: International journal of cancer. Journal international du cancer, Vol. 70, Issue 4, pp. 396-400, 1997 (PubMed).

Martinet, Bohadana, Fagerström: "Would alternate tobacco products use be better than smoking?" in: Lung cancer (Amsterdam, Netherlands), Vol. 53, Issue 1, pp. 1-4, 2006 (PubMed).

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