Chemokine (C-C Motif) Receptor 1 (CCR1) (AA 305-319) antibody

Antigen: Chemokine (C-C Motif) Receptor 1 (CCR1)

Synonyms: CKR1, CD191, CKR-1, HM145, CMKBR1, MIP1aR, SCYAR1

Epitope: AA 305-319

Clonality: Monoclonal (Y1)

Host: Mouse

Reactivity: Human

Application: Enzyme Immunoassay (EIA)

Catalog no.: ABIN452617

Additional Information

Characteristics: Synonyms: C-C chemokine receptor type 1, C-C CKR-1, CC-CKR-1, CCR-1, CMKBR1, CMKR1, SCYAR1,HM145, LD78 receptor, Macrophage inflammatory protein 1-alpha receptor, MIP1 alphaReceptor, RANTES-R

Alternative name: CD191 / CCR1

Gene ID: 1230

Swiss-Prot: P32246

Immunogen: A 15 amino-acid peptide corresponding to the amino acid sequence 305-319 of HumanCCR1, conjugated with KLH for immunization.

Cross-Reactivity: Human

Isotype: IgG1  (Matching secondary antibodies)

Clone: Y1

Description: This gene encodes a member of the beta chemokine receptor family, which is predicted tobe a seven transmembrane protein similar to G protein coupled receptors. The ligands ofthis receptor include macrophage inflammatory protein 1 alpha (MIP1 alpha), regulated onactivation normal T expressed and secreted protein (RANTES), monocyte chemoattractantprotein 3 (MCP3), and myeloid progenitor inhibitory factor 1 (MPIF1). Chemokines and theirreceptors mediated signal transduction are critical for the recruitment of effector immunecells to the site of inflammation. Knockout studies of the mouse homolog suggested theroles of this gene in host protection from inflammatory response, and susceptibility tovirus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2,CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p. Receptors for the C-C chemokine family include CCR-1, CCR-2A, CCR-3, CCR-4, CCR-5 and theDuffy blood group antigen. The C-C receptors are important in the function of T cell chemotaxis and migration ofphagocytic cells to sites of inflammation.

Specificity: This antibody recognizes the above peptide conjugated KLH in EIA. It does not cross reactwith KLH, BSA and HSA. Species Reactivity: Tested: Human.

Application Details

Application Notes: ELISA. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Purification: Purified

Buffer: 0.01 M PBS, pH 7.0 without preservatives.Reconstitution: Restore with Double distillated water to adjust the final concentration to1.0 mg/ml.

Storage: Store the antibody at -20°C. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Restrictions: For Research Use only