Growth Differentiation Factor 15 (GDF15) (C-Term) antibody

Details for Product No. ABIN452672
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Antigen
Synonyms PDF, MIC1, PLAB, MIC-1, NAG-1, PTGFB, GDF-15, SBF, GDF15
Epitope
C-Term
(39), (25), (5), (4), (4), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(129), (56), (34), (8), (8)
Host
Rabbit
(122), (15), (7), (4), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(20), (14), (3), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(129), (109), (26), (25), (10), (10), (10), (7), (5), (3), (2), (1), (1)
Pubmed 2 references available
Catalog no. ABIN452672
Quantity 0.1 mg
Price
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Immunogen MBP-tagged recombinant protein corresponding to full-length mature Mouse NAG-1 protein. Excess reactivity to MBP was removed via cross-adsorption chromatography.
Isotype IgG
Specificity This antibody reacts with endogenous NAG-1 protein.
Purification Affinity Chromatography on Protein A
Alternative Name GDF15
Background Non-steroidal anti-inflammatory drug (NSAID) activated gene (NAG-1) is a member of the transforming growth factor-beta (TGF-beta) superfamily. NAG-1 is also known as Macrophage Inhibitory Cytokine-1 (MIC-1), Growth Differentiation Factor 15 (GDF15), Placental Bone Morphogenetic Protein (PLAB), or Prostate Derived Factor (PDF). NAG-1 is expressed in human placenta, prostate and colon. It possesses antitumorigenic and proapoptotic activities. NAG-1 expression is dramatically increased in inflammation, injury and malignancy. Increase of NAG-1 expression is a feature of many cancers including breast, colon, pancreas and prostate. In a number of studies, NAG-1 expression was increased by a number of NSAIDs. This increase in expression may correlate with the chemopreventive effect NSAIDs seem to have with certain cancers. NAG-1 expression is also induced by PPAR gamma ligands and by several dietary compounds such as conjugated linoleic acids (CLAs), naturally occurring fatty acids in ruminant food products, indoles, epicatechin gallate, and genistein. Induced expression of NAG-1 results in stimulation of apoptosis and inhibition of cell growth. Inhibition of NAG-1 induced expression by small interference RNA (siRNA) results in repression of induced apoptosis. NAG-1 expression is regulated by a numbers of transcription factors such as ERG-1 and Sp1. EGR-1 may be necessary for NSAID-induced NAG-1 expression. The study of expression of NAG-1 proteins, including variants, is important to define their potential role as serum biomarkers for cancer diagnosis, treatment monitoring, epidemiology study, and nutrition surveys.
Alternate names: GDF-15, Growth/differentiation factor 15, MIC-1, MIC1, Macrophage inhibitory cytokine 1, NAG-1, NRG-1, NSAID-activated gene 1 protein, NSAID-regulated gene 1 protein, PDF, PLAB, PTGFB, Placental TGF-beta, Placental bone morphogenetic protein, Prostate differentiation factor
NCBI Accession 10090
UniProt Q9Z0J7
Research Area Cardiovascular, Hypertrophy, Extracellular Matrix
Application Notes ELISA: 1/10,000. For detection of NAG-1 in Mouse serum, a sandwich ELISA is suggestedusing this antibody in combination with anti-NAG-1/GDF15 (N-terminal) specific antibodies.
Restrictions For Research Use only
Format Liquid
Concentration 1.13 mg/mL (by UV absorbance at 280 nm)
Buffer 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01% (w/v) Sodium Azide
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at-20°C for longer.
Expiry Date 12 months
Supplier Images
anti-Growth Differentiation Factor 15 (GDF15) (C-Term) antibody anti-Growth Differentiation Factor 15 (GDF15) (C-Term) antibody
Background publications Lindmark, Zheng, Wiklund et al.: "H6D polymorphism in macrophage-inhibitory cytokine-1 gene associated with prostate cancer." in: Journal of the National Cancer Institute, Vol. 96, Issue 16, pp. 1248-54, 2004 (PubMed).

Baek, Eling: "Changes in gene expression contribute to cancer prevention by COX inhibitors." in: Progress in lipid research, Vol. 45, Issue 1, pp. 1-16, 2006 (PubMed).

Hosts (122), (15), (7), (4), (1)
Reactivities (129), (56), (34), (8), (8)
Applications (129), (109), (26), (25), (10), (10), (10), (7), (5), (3), (2), (1), (1)
Conjugates (20), (14), (3), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (39), (25), (5), (4), (4), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
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