ALS2 antibody (C-Term)

Catalog No. ABIN452733

Product Details anti-ALS2 Antibody

Target: ALS2 (Amyotrophic Lateral Sclerosis 2 (Juvenile) (ALS2))

Binding Specificity: C-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ALS2 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody detects Alsin / ALS2 at C-term.

Cross-Reactivity (Details): Species reactivity (tested):Human, Mouse.

Purification: Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS

Immunogen: KLH conjugated synthetic peptide selected from the C-terminal region of human ALS2

Application Details

Application Notes: Western blot: 1: 50 - 1: 100. ELISA: 1: 1,000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.

Target Details for ALS2

Target: ALS2 (Amyotrophic Lateral Sclerosis 2 (Juvenile) (ALS2))

Alternative Name: Alsin / ALS2 (ALS2 Products)

Synonyms: als2 antibody, si:dkey-33m14.1 antibody, ALS2CR6 antibody, ALSJ antibody, IAHSP antibody, PLSJ antibody, 3222402C23Rik antibody, 9430073A21Rik antibody, Als2cr6 antibody, Alsin antibody, mKIAA1563 antibody, amyotrophic lateral sclerosis 2a (juvenile) antibody, alsin antibody, ALS2, alsin Rho guanine nucleotide exchange factor antibody, amyotrophic lateral sclerosis 2 (juvenile) antibody, als2a antibody, CpipJ_CPIJ008258 antibody, CpipJ_CPIJ008260 antibody, ALS2 antibody, Als2 antibody

Background: ALS2 contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in its gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis.Synonyms: ALS2CR6, Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein, Amyotrophic lateral sclerosis protein 2, KIAA1563

Molecular Weight: 183666 Da

Gene ID: 57679

NCBI Accession: NP_001129217

UniProt: Q96Q42

Pathways: Skeletal Muscle Fiber Development