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CBFB antibody (Middle Region)
CBFB
Reactivity: Human
WB, EIA
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-CBFB Antibody
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Target
See all CBFB Antibodies
CBFB
(Core-Binding Factor, beta Subunit (CBFB))
Binding Specificity
All epitopes for CBFB antibodies
Middle Region
Reactivity
All reactivities for CBFB antibodies
Human
Host
All hosts for CBFB antibodies
Rabbit
Clonality
All clonalities for CBFB antibodies
Polyclonal
Conjugate
All conjugates for CBFB antibodies
This CBFB antibody is un-conjugated
Application
All applications for CBFB antibodies
Western Blotting (WB), Enzyme Immunoassay (EIA)
Specificity
This antibody detects CBFB at Center.
Cross-Reactivity (Details)
Species reactivity (tested):Human
Purification
Purified through a protein A column, followed by peptide affinity purification
Immunogen
KLH conjugated synthetic peptide selected from the Center region of human CBFB
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Alternatives
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Application Details
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Application Notes
Western blot: 1: 100 - 1: 500. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
0.25 mg/mL
Buffer
PBS with 0.09 % (W/V) sodium azide
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
4 °C/-20 °C
Storage Comment
Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.
Target Details for CBFB
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Target
CBFB
(Core-Binding Factor, beta Subunit (CBFB))
Alternative Name
CBFB (CBFB Products )
Synonyms
PEBP2B antibody, Cbfb antibody, pebp2b antibody, Pebp2 antibody, CBFB antibody, unp1266 antibody, cbf-beta antibody, cbfbeta antibody, pea2-beta antibody, pebp2-beta antibody, AI893578 antibody, PEA2 antibody, PEBP2b antibody, Pebpb2 antibody, core-binding factor beta subunit antibody, core binding factor beta subunit antibody, core-binding factor, beta subunit antibody, core-binding factor, beta subunit S homeolog antibody, core binding factor beta antibody, CBFB antibody, Cbfb antibody, cbfb antibody, cbfb.S antibody
Background
CBFB is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit, it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters.Synonyms: CBF beta, CBF-beta, Core-binding factor beta, PEA2-beta, PEBP2-beta, Polyomavirus enhancer-binding protein 2 beta subunit, SL3-3 enhancer factor 1 subunit beta, SL3/AKV core-binding factor beta subunit
Molecular Weight
21508 Da
Gene ID
865
NCBI Accession
NP_001746
UniProt
Q13951
Pathways
Regulation of Lipid Metabolism by PPARalpha
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