MTA2 antibody (C-Term)

Catalog No. ABIN453277

Product Details anti-MTA2 Antibody

Target: MTA2 (Metastasis Associated 1 Family, Member 2 (MTA2))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MTA2 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody reacts to MTA2.

Purification: Saturated Ammonium Sulfate (SAS) precipitation

Immunogen: KLH conjugated synthetic peptide selected from the C-terminal region of human MTA2

Application Details

Application Notes: ELISA: 1/1,000. Western blotting: 1/50 - 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for MTA2

Target: MTA2 (Metastasis Associated 1 Family, Member 2 (MTA2))

Alternative Name: MTA2 (MTA2 Products)

Synonyms: MTA1L1 antibody, PID antibody, fd61b05 antibody, wu:fd61b05 antibody, wu:fi29g02 antibody, zgc:63487 antibody, pid antibody, mta1l1 antibody, MTA2 antibody, DKFZp470E0911 antibody, AW550797 antibody, Mata1l1 antibody, Mta1l1 antibody, mmta2 antibody, metastasis associated 1 family member 2 antibody, metastasis associated 1 family, member 2 antibody, metastasis-associated gene family, member 2 antibody, metastasis associated 1 family member 2 L homeolog antibody, MTA2 antibody, mta2 antibody, Mta2 antibody, mta2.L antibody

Background: MTA2 is a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small family of different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacteylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis.Synonyms: MTA1-L1, MTA1L1, Metastasis-associated 1-like 1, Metastasis-associated protein MTA2, PID, p53 target protein in deacetylase complex

Gene ID: 9219

NCBI Accession: NP_004730

UniProt: O94776

Pathways: Chromatin Binding