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PSME2 antibody (Middle Region)

PSME2 Reactivity: Human, Mouse WB, EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN453316
  • Target See all PSME2 Antibodies
    PSME2 (Proteasome (Prosome, Macropain) Activator Subunit 2 (PA28 Beta) (PSME2))
    Binding Specificity
    • 6
    • 6
    • 6
    • 6
    • 5
    • 5
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    Middle Region
    Reactivity
    • 46
    • 20
    • 12
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    Human, Mouse
    Host
    • 39
    • 6
    • 1
    Rabbit
    Clonality
    • 43
    • 3
    Polyclonal
    Conjugate
    • 25
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PSME2 antibody is un-conjugated
    Application
    • 35
    • 24
    • 19
    • 13
    • 5
    • 4
    • 3
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Specificity
    This antibody reacts to PSME2.
    Purification
    Affinity chromatography on Protein A
    Immunogen
    KLH conjugated synthetic peptide selected from the Center region of human PSME2
    Top Product
    Discover our top product PSME2 Primary Antibody
  • Application Notes
    ELISA: 1/1,000. Western blotting: 1/100 - 1/500.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.25 mg/mL
    Buffer
    PBS with 0.09 % (W/V) sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    PSME2 (Proteasome (Prosome, Macropain) Activator Subunit 2 (PA28 Beta) (PSME2))
    Alternative Name
    PSME2 / REG-beta (PSME2 Products)
    Synonyms
    unp309 antibody, PA28B antibody, PA28beta antibody, REGbeta antibody, AA589371 antibody, AI788882 antibody, PA28b antibody, proteasome activator subunit 2 antibody, proteasome (prosome, macropain) activator subunit 2 (PA28 beta) antibody, psme2 antibody, PSME2 antibody, Psme2 antibody
    Background
    The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. PSME2 is the beta subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon.Synonyms: 11S regulator complex subunit beta, Activator of multicatalytic protease subunit 2, PA28b, PA28beta, Proteasome activator, Proteasome activator 28 subunit beta, Proteasome activator complex subunit 2
    Gene ID
    5721
    NCBI Accession
    NP_002809
    UniProt
    Q9UL46
    Pathways
    Mitotic G1-G1/S Phases, DNA Replication, Positive Regulation of Endopeptidase Activity, Synthesis of DNA
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