TDG antibody (C-Term)

Catalog No. ABIN453411

Product Details anti-TDG Antibody

Target: TDG (Thymine-DNA Glycosylase (TDG))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TDG antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody reacts to TDG.

Purification: Saturated Ammonium Sulfate (SAS) precipitation

Immunogen: KLH conjugated synthetic peptide selected from the C-terminal region of human TDG

Application Details

Application Notes: ELISA: 1/1,000. Western blotting: 1/50 - 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for TDG

Target: TDG (Thymine-DNA Glycosylase (TDG))

Alternative Name: TDG (TDG Products)

Synonyms: 5-MCDG antibody, wu:fb44b11 antibody, zgc:110622 antibody, MGC82456 antibody, MGC89441 antibody, E130317C12Rik antibody, JZA-3 antibody, Jza1 antibody, hTDG antibody, thymine DNA glycosylase antibody, thymine DNA glycosylase, tandem duplicate 1 antibody, putative g/t mismatch-specific thymine DNA glycosylase antibody, G/T mismatch-specific thymine DNA glycosylase antibody, thymine DNA glycosylase S homeolog antibody, thymine-DNA glycosylase antibody, TDG antibody, tdg.1 antibody, Smp_149220 antibody, Tsp_05734 antibody, tdg.S antibody, tdg antibody, Tdg antibody

Background: The protein TDG belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine.Synonyms: G/T mismatch-specific thymine DNA glycosylase

Gene ID: 6996

NCBI Accession: NP_003202

UniProt: Q13569

Pathways: DNA Damage Repair, Chromatin Binding