NOD1 antibody (Nucleotide-Binding Oligomerization Domain Containing 1) (C-Term)

Details for Product anti-NOD1 Antibody No. ABIN453551, Supplier: Log in to see
Antigen
  • CARD4
  • CLR7.1
  • NLRC1
  • C230079P11
  • Card4
  • F830007N14Rik
  • Nlrc1
  • RGD1562269
  • nucleotide-binding oligomerization domain containing 1
  • NOD1
  • Nod1
Alternatives
anti-Human NOD1 antibody for ELISA
Epitope
C-Term
36
17
9
7
6
5
5
5
4
3
3
3
3
2
2
1
1
1
1
1
1
1
Reactivity
Human
113
44
26
1
1
1
1
Host
Rabbit
110
15
6
Clonality
Polyclonal
Conjugate
This NOD1 antibody is un-conjugated
6
6
5
5
5
5
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
123
68
25
24
13
6
6
6
4
2
2
1
1
Options
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Immunogen KLH conjugated synthetic peptide selected from the C-terminal region of Human CARD4. Genename: NOD1
Specificity This antibody recognizes CARD4 / NOD1 (C-term).
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Affinity Chromatography on Protein A.
Alternative Name CARD4 / NOD1 (NOD1 Antibody Abstract)
Background CARD4 is a member of the NOD (nucleotide-binding oligomerization domain) family. This member is a cytosolic protein. It contains an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and 10 tandem leucine-rich repeats (LRRs) in its C terminus. The CARD is involved in apoptotic signaling, LRRs participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. This protein is an intracellular pattern-recognition receptor (PRR) that initiates inflammation in response to a subset of bacteria through the detection of bacterial diaminopimelic acid.Synonyms: Caspase recruitment domain-containing protein 4, Nucleotide-binding oligomerization domain-containing protein 1
Molecular Weight 107691 Da
Gene ID 10392
NCBI Accession NP_006083
UniProt Q9Y239
Research Area Signaling, Transcription Factors
Pathways Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades
Application Notes ELISA: 1/1,000. Western blotting: 1/100-1/500. Immunohistochemistry: 1/50-1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-NOD1 antibody (Nucleotide-Binding Oligomerization Domain Containing 1) (C-Term) (ABIN453551) AP17920PU-N CARD4 antibody staining of Formalin-Fixed, Paraffin-Embedded Human skelet...
Western Blotting (WB) image for anti-NOD1 antibody (Nucleotide-Binding Oligomerization Domain Containing 1) (C-Term) (ABIN453551) Western blot analysis of CARD4 Antibody (C-term) in HL-60 cell line lysates (35ug/lan...
Background publications Inohara, Koseki, Lin, del Peso, Lucas, Chen, Ogura, Núñez: "An induced proximity model for NF-kappa B activation in the Nod1/RICK and RIP signaling pathways." in: The Journal of biological chemistry, Vol. 275, Issue 36, pp. 27823-31, 2000 (PubMed).

Inohara, Koseki, del Peso, Hu, Yee, Chen, Carrio, Merino, Liu, Ni, Núñez: "Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB." in: The Journal of biological chemistry, Vol. 274, Issue 21, pp. 14560-7, 1999 (PubMed).