anti-NOD1 antibody (Nucleotide-Binding Oligomerization Domain Containing 1) (C-Term)

Details for Product anti-NOD1 Antibody No. ABIN453551
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Synonyms CARD4, CLR7.1, NLRC1, C230079P11, Card4, F830007N14Rik, Nlrc1, RGD1562269
(29), (15), (12), (7), (5), (4), (4), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1)
(104), (49), (31), (2), (2), (2), (1)
(101), (13), (6)
This NOD1 antibody is un-conjugated
(7), (7), (6), (5), (5), (5), (1), (1), (1), (1), (1), (1), (1), (1)
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(104), (59), (21), (15), (10), (10), (6), (4), (4), (4), (3), (2)
Pubmed 2 references available
Quantity 0.4 mL
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Availability Will be delivered in 6 to 8 Business Days
Immunogen KLH conjugated synthetic peptide selected from the C-terminal region of Human CARD4. Genename: NOD1
Specificity This antibody recognizes CARD4 / NOD1 (C-term).
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Affinity Chromatography on Protein A.
Alternative Name CARD4 / NOD1 (NOD1 Antibody Abstract)
Background CARD4 is a member of the NOD (nucleotide-binding oligomerization domain) family. This member is a cytosolic protein. It contains an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and 10 tandem leucine-rich repeats (LRRs) in its C terminus. The CARD is involved in apoptotic signaling, LRRs participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. This protein is an intracellular pattern-recognition receptor (PRR) that initiates inflammation in response to a subset of bacteria through the detection of bacterial diaminopimelic acid.Synonyms: Caspase recruitment domain-containing protein 4, Nucleotide-binding oligomerization domain-containing protein 1
Molecular Weight 107691 Da
Gene ID 10392
NCBI Accession NP_006083
UniProt Q9Y239
Research Area Signaling, Transcription Factors
Application Notes ELISA: 1/1,000. Western blotting: 1/100-1/500. Immunohistochemistry: 1/50-1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-NOD1 antibody (Nucleotide-Binding Oligomerization Domain Containing 1) (C-Term) (ABIN453551) AP17920PU-N CARD4 antibody staining of Formalin-Fixed, Paraffin-Embedded Human skelet...
Western Blotting (WB) image for anti-NOD1 antibody (Nucleotide-Binding Oligomerization Domain Containing 1) (C-Term) (ABIN453551) Western blot analysis of CARD4 Antibody (C-term) (AP17920PU-N) in HL-60 cell line lys...
Background publications Inohara, Koseki, Lin et al.: "An induced proximity model for NF-kappa B activation in the Nod1/RICK and RIP signaling pathways." in: The Journal of biological chemistry, Vol. 275, Issue 36, pp. 27823-31, 2000 (PubMed).

Inohara, Koseki, del Peso et al.: "Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB." in: The Journal of biological chemistry, Vol. 274, Issue 21, pp. 14560-7, 1999 (PubMed).

Catalog No. ABIN453551
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