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Details for Product No. ABIN453551

Nucleotide-Binding Oligomerization Domain Containing 1 (NOD1) (C-Term) antibody

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Antigen
Synonyms CARD4, NLRC1, CLR7.1, C230079P11, Card4, F830007N14Rik, Nlrc1, RGD1562269
Epitope
»Alternatives C-Term
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Pubmed 2 references available
Catalog no. ABIN453551
Quantity 0.4 mL
Price
346.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen KLH conjugated synthetic peptide selected from the C-terminal region of Human CARD4. Genename: NOD1
Specificity This antibody recognizes CARD4 / NOD1 (C-term). Species Reactivity: Tested: Human.
Purification Affinity Chromatography on Protein A.
Alternative Name CARD4 / NOD1
Background CARD4 is a member of the NOD (nucleotide-binding oligomerization domain) family. This member is a cytosolic protein. It contains an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and 10 tandem leucine-rich repeats (LRRs) in its C terminus. The CARD is involved in apoptotic signaling, LRRs participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. This protein is an intracellular pattern-recognition receptor (PRR) that initiates inflammation in response to a subset of bacteria through the detection of bacterial diaminopimelic acid.
Alternate names: Caspase recruitment domain-containing protein 4, Nucleotide-binding oligomerization domain-containing protein 1
Molecular Weight 107691 Da
Gene ID 10392
NCBI Accession NP_006083
UniProt Q9Y239
Research Area Signaling, Transcription Factors
Application Notes ELISA: 1/1,000. Western blotting: 1/100-1/500. Immunohistochemistry: 1/50-1/100. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09% (w/v) Sodium Azide as preservative.
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Inohara, Koseki, del Peso et al.: "Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB." in: The Journal of biological chemistry, Vol. 274, Issue 21, pp. 14560-7, 1999 (PubMed).

Inohara, Koseki, Lin et al.: "An induced proximity model for NF-kappa B activation in the Nod1/RICK and RIP signaling pathways." in: The Journal of biological chemistry, Vol. 275, Issue 36, pp. 27823-31, 2000 (PubMed).

Alternatives for antigen "Nucleotide-Binding Oligomerization Domain Containing 1 (NOD1)", type "Antibodies"
Hosts (51), (3), (3)
Reactivities (54), (31), (23), (1)
Applications (47), (20), (15), (10), (9), (7), (7), (3), (2), (2), (2), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (17), (4), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1)
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