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Nucleotide-Binding Oligomerization Domain Containing 1 (NOD1) (C-Term) antibody

Details for Product No. ABIN453551
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Antigen
Synonyms CARD4, CLR7.1, NLRC1, C230079P11, Card4, F830007N14Rik, Nlrc1, RGD1562269
Epitope
C-Term
(26), (8), (7), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Reactivity
Human
(66), (35), (25)
Host
Rabbit
(67), (3), (3)
Clonality
Polyclonal
Conjugate
Un-conjugated
(4), (4), (4), (3), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(63), (39), (15), (14), (11), (10), (9), (8), (3), (2), (2)
Pubmed 2 references available
Quantity 0.4 mL
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Catalog No. ABIN453551
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Immunogen KLH conjugated synthetic peptide selected from the C-terminal region of Human CARD4. Genename: NOD1
Specificity This antibody recognizes CARD4 / NOD1 (C-term). Species Reactivity: Tested: Human.
Purification Affinity Chromatography on Protein A.
Alternative Name CARD4 / NOD1
Background CARD4 is a member of the NOD (nucleotide-binding oligomerization domain) family. This member is a cytosolic protein. It contains an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and 10 tandem leucine-rich repeats (LRRs) in its C terminus. The CARD is involved in apoptotic signaling, LRRs participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. This protein is an intracellular pattern-recognition receptor (PRR) that initiates inflammation in response to a subset of bacteria through the detection of bacterial diaminopimelic acid.
Alternate names: Caspase recruitment domain-containing protein 4, Nucleotide-binding oligomerization domain-containing protein 1
Molecular Weight 107691 Da
Gene ID 10392
NCBI Accession NP_006083
UniProt Q9Y239
Research Area Signaling, Transcription Factors
Application Notes ELISA: 1/1,000. Western blotting: 1/100-1/500. Immunohistochemistry: 1/50-1/100. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09% (w/v) Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Inohara, Koseki, del Peso et al.: "Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB." in: The Journal of biological chemistry, Vol. 274, Issue 21, pp. 14560-7, 1999 (PubMed).

Inohara, Koseki, Lin et al.: "An induced proximity model for NF-kappa B activation in the Nod1/RICK and RIP signaling pathways." in: The Journal of biological chemistry, Vol. 275, Issue 36, pp. 27823-31, 2000 (PubMed).

Validation Images
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