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MCAM antibody (Middle Region)

MCAM Reactivity: Human WB, EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN453743
  • Target See all MCAM Antibodies
    MCAM (Melanoma Cell Adhesion Molecule (MCAM))
    Binding Specificity
    • 16
    • 13
    • 11
    • 6
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivity
    • 127
    • 48
    • 47
    • 15
    • 14
    • 9
    • 9
    • 8
    • 6
    • 2
    Human
    Host
    • 95
    • 56
    • 1
    • 1
    • 1
    • 1
    Rabbit
    Clonality
    • 85
    • 70
    Polyclonal
    Conjugate
    • 75
    • 14
    • 13
    • 10
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This MCAM antibody is un-conjugated
    Application
    • 91
    • 72
    • 66
    • 44
    • 21
    • 20
    • 18
    • 12
    • 12
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Specificity
    This antibody reacts to CD146.
    Purification
    Saturated Ammonium Sulfate (SAS) precipitation
    Immunogen
    KLH conjugated synthetic peptide selected from the Center region of human MCAM
    Top Product
    Discover our top product MCAM Primary Antibody
  • Application Notes
    ELISA: 1/1,000. Western blotting: 1/50 - 1/100.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.25 mg/mL
    Buffer
    PBS with 0.09 % (W/V) sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    MCAM (Melanoma Cell Adhesion Molecule (MCAM))
    Alternative Name
    CD146 (MCAM Products)
    Synonyms
    CD146 antibody, MUC18 antibody, Muc18 antibody, 1-gicerin antibody, AV025631 antibody, CD149 antibody, s-endo antibody, s-gicerin antibody, cd146 antibody, gicerin antibody, id:ibd3512 antibody, mcam antibody, MCAM antibody, melanoma cell adhesion molecule antibody, melanoma cell adhesion molecule b antibody, MCAM antibody, Mcam antibody, mcamb antibody
    Background
    MCAM plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. It could be an adhesion molecule active in neural crest cells during embryonic development. It acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2, and a transient increase in the intracellular calcium concentration.Synonyms: A32, CD146, Cell surface glycoprotein P1H12, MCAM, MUC18, Melanoma cell adhesion molecule, Melanoma-associated antigen MUC18, S-endo 1 endothelial-associated antigen
    Gene ID
    4162
    NCBI Accession
    NP_006491
    UniProt
    P43121
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