SAA antibody (Biotin)

Catalog No. ABIN453894

Product Details anti-SAA Antibody (Biotin)

Target: SAA (Serum Amyloid A (SAA))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SAA antibody is conjugated to Biotin

Application: Enzyme Immunoassay (EIA), ELISA (Detection)

Specificity: This antibody reacts with natural and recombinant SAA. Does not show any cross-reaction with other human cytokines or growth factors tested such as IL-1beta, IL-8, MCAF, TGF-beta and EGF.

Purification: Affinity Chromatography on Protein G

Immunogen: Highly purified recombinant Human SAA (MW: 12 kDa)

Clone: 607

Isotype: IgG2a

Application Details

Application Notes: ELISA.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.01 M PBS, pH 7.0±0.1, 0.1 % Proclin-300, 1 % Gelatin

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store the antibody at -20 °C. Can be shipped at 2 - 8 °C.

Target Details for SAA

Target: SAA (Serum Amyloid A (SAA))

Alternative Name: Serum Amyloid A Protein (SAA) (SAA Products)

Synonyms: PIG4 antibody, SAA antibody, SAA2 antibody, TP53I4 antibody, zgc:103580 antibody, saa antibody, SAA1 antibody, Saa-1 antibody, Saa2 antibody, serum amyloid A1 antibody, serum amyloid A antibody, serum amyloid A protein antibody, serum amyloid A-3 antibody, HPS5, biogenesis of lysosomal organelles complex 2 subunit 2 antibody, serum amyloid A2 antibody, serum amyloid A 1 antibody, SAA1 antibody, saa antibody, LOC476879 antibody, SAA antibody, SAA3 antibody, HPS5 antibody, SAA2 antibody, Saa1 antibody, LOC100270725 antibody

Background: The serum amyloid A (SAA) family comprises a number of differentially expressed lipoproteins, acute phase SAA1 and SAA2, the former being a major component in plasma, and constitutive SAA's (C-SAAs). Although the liver is the primary site of synthesis of both SAA types, extrhepatic production has been reported. The in vivo concentrations increase by as much as 1000 fold during inflammation. Several studies have expressed it's importance in the diagnosis and monitoring of various diseases. Pathological SAA values are often detected in association with normal CRP concentrations. SAA rises earlier and more sharply than CRP. SAA enhances the binding of HDL's to macrophages and thus helps the delivery of lipid to sites of injury for use in tissue repair. It is thus thought to be an integral part of the disease process. In addition, recent experiments suggest that SAA may play a "houekeeping" role in normal human tissues. Elevated levels of SAA over time predispose secondary amyloidosis, extracellular accumulation of amyloid fibrils, derived from a circulating precursor, in various tissues and organs. The most common form of amyloidosis occurs secondary to chronic inflammatory disease, particularly rheumatoid artheritis.Synonyms: SAA1, SAA2

Gene ID: 6288

NCBI Accession: NP_000322

UniProt: P02735