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GDF15 antibody (Growth Differentiation Factor 15) (N-Term)

Details for Product anti-GDF15 Antibody No. ABIN453965, Supplier: Log in to see
Antigen
  • GDF-15
  • GDF15
  • MIC-1
  • MIC1
  • NAG-1
  • PDF
  • PLAB
  • PTGFB
  • SBF
Epitope
N-Term, Variant D
79
54
17
16
15
13
11
7
6
5
5
5
3
3
2
2
2
1
1
1
1
1
1
1
Reactivity
Chimpanzee, Human, Macaque, Mouse (Murine), Rat (Rattus)
289
83
39
6
6
2
2
Host
Rabbit
237
50
19
6
Clonality
Polyclonal
Conjugate
This GDF15 antibody is un-conjugated
37
30
13
6
5
5
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
247
230
85
45
28
11
11
7
5
5
1
1
Supplier
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Immunogen Synthetic peptide corresponding to a region near the amino terminal end of Human NAG-1 protein. A residue of Cysteine was added to facilitate coupling to KLH
Isotype IgG
Specificity This antibody specifically reacts with a D variant sequence of Human NAG-1 protein.
Cross-Reactivity (Details) Species reactivity (expected):Chimpanzee, Macaque, Mouse, Rat.
Species reactivity (tested):Human.
Purification Immunoaffinity Chromatography
Alternative Name GDF15 (GDF15 Antibody Abstract)
Background Non-steroidal antiinflammatory drug (NSAID) activated gene (NAG-1) is a member of the transforming growth factor-beta (TGF-beta) superfamily. NAG-1 is also known as Macrophage Inhibitory Cytokine-1 (MIC-1), Growth Differentiation Factor 15 (GDF15), Placental Bone Morphogenetic Protein (PLAB), or Prostate Derived Factor (PDF). NAG-1 is expressed in human placenta, prostate and colon. It possesses antitumorigenic and proapoptotic activities. NAG-1 expression is dramatically increased in inflammation, injury and malignancy. Increase of NAG-1 expression is a feature of many cancers including breast, colon, pancreas and prostate. In a number of studies, NAG-1 expression was increased by a number of NSAIDs. This increase in expression may correlate with the chemopreventive effect NSAIDs seem to have with certain cancers. NAG-1 expression is also induced by PPAR gamma ligands and by several dietary compounds such as conjugated linoleic acids (CLAs), naturally occurring fatty acids in ruminant food products, indoles, epicatechin gallate, and genistein. The induced expression of NAG-1 results in a stimulation of apoptosis and inhibition of cell growth. Inhibition of NAG-1 induced expression by small interference RNA (siRNA) results in repression of induced apoptosis. NAG-1 expression is regulated by a numbers of transcription factors such as ERG-1 and Sp1. EGR-1 may be necessary for NSAID-induced NAG-1 expression. The study of expression of NAG-1 proteins, including variants, is important to define their potential role as serum biomarkers for cancer diagnosis, treatment monitoring, epidemiology study, and nutrition surveys.Synonyms: GDF-15, Growth/differentiation factor 15, MIC-1, MIC1, Macrophage inhibitory cytokine 1, NAG-1, NRG-1, NSAID-activated gene 1 protein, NSAID-regulated gene 1 protein, PDF, PLAB, PTGFB, Placental TGF-beta, Placental bone morphogenetic protein, Prostate differentiation factor
Gene ID 9518
NCBI Accession NP_004855
UniProt Q99988
Research Area Cardiovascular, Hypertrophy, Extracellular Matrix
Application Notes ELISA: 1/400. Western Blot: 1000 - 2000.
Restrictions For Research Use only
Concentration 0.56 mg/mL (by UV absorbance at 280 nm)
Buffer 0.02 M Potassium Phosphate, 0.12 M Sodium Chloride, pH 7.2, 0.09 % (w/v) Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Supplier Images
 image for anti-GDF15 antibody (Growth Differentiation Factor 15) (N-Term) (ABIN453965) anti-Growth Differentiation Factor 15 (GDF15) (N-Term), (Variant D) antibody
Background publications Baek, Eling: "Changes in gene expression contribute to cancer prevention by COX inhibitors." in: Progress in lipid research, Vol. 45, Issue 1, pp. 1-16, 2006

Lindmark, Zheng, Wiklund, Bensen, Bälter, Chang, Hedelin, Clark, Stattin, Meyers, Adami, Isaacs, Grönberg, Xu: "H6D polymorphism in macrophage-inhibitory cytokine-1 gene associated with prostate cancer." in: Journal of the National Cancer Institute, Vol. 96, Issue 16, pp. 1248-54, 2004