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CD44 (CD44) antibody (FITC)

Antigen

CD44 (CD44)
Synonyms IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1, CDW44, CSPG8, HCELL, MUTCH-I, ECMR-III, MGC10468
Clonality Monoclonal (IM7)
Host
Reactivity
Alternatives

Human, Mouse (Murine), Dog (Canine), Horse (Equine), Cat (Feline)
Conjugate
Application
Alternatives Flow Cytometry (FACS)
Catalog no. ABIN457344
Quantity 0.1 mg  (0.5 mg/ml)  (Variants)
Price 247.00 $   Plus shipping costs $35.00
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Additional Information
Application Details Alternatives Variants back to top

Alternative name CD44
Immunogen Dexamethasone-induced cells of the SJL mouse spontaneous myeloid leukemia M1
Isotype IgG2b
Clone IM7
Description CD44 is a transmembrane glycoprotein expressed on the surface of most cells, whichserves as a receptor for hyaluronan. CD44 mediates angiogenesis, cell adhesion,proliferation and migration, it is thus important for lymphocyte activation, recirculation andhoming. Although CD44 functions are essential for physiological activities of normal cells,elevated CD44 expression correlates with poor prognosis in many carcinomas, facilitatingtumour growth and metastasis, antiapoptosis and directional motility of cancer cells.
Specificity The rat monoclonal antibody IM7 reacts with CD44 antigen (Phagocyte glycoprotein 1), an80-95 kDa transmembrane glycoprotein (hyaladherin family) present on the most of cellsand tissues (leukocytes, endothelial cells, mesenchymal cells, etc.), it is negative onplatelets and hepatocytes. The antibody reacts with all isoforms of mouse CD44.

Application Details
Alternatives Variants back to top

Application Notes The reagent is designed for Flow Cytometry analysis. Suggested working concentration is 2 µg/ml. Indicated dilution is recommended startingpoint for use of this product. Working concentrations should be determined by the investigator.
Concentration 0.5 mg/ml
Buffer Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Storage Store in the dark at 2-8 o C. Do not freeze. Avoid prolonged exposure to light. Do not use after expiration date stamped on vial label.Short-term exposure to room temperature should not affect the quality of the reagent.However, if reagent is stored under any conditions other than those specified, the conditions must be verified by the user.
Research Area Stem Cells, Hematopoietic Progenitors, CD Antigens, Surface Receptors of Immune Cells, Cancer, Cell Cycle
Restrictions For Research Use only

Alternatives
Application Details Variants back to top

Alternatives for antigen "CD44 (CD44)", type "Antibodies"
Hosts Mouse (295), Rabbit (130), Rat (105), Goat (2), Human (1)
Reactivities Human (346), Mouse (Murine) (194), Rat (Rattus) (115), Dog (Canine) (62), Pig (Porcine) (52), Rabbit (51), Cow (Bovine) (35), Chicken (33), Horse (Equine) (27), Monkey (13), Cat (Feline) (12), Sheep (Ovine) (8), Baboon (5), Bird (Avian) (4), Goat (2)
Applications Flow Cytometry (FACS) (411), Western Blotting (WB) (132), Immunohistochemistry (Frozen Sections) (IHC (fro)) (120), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (119), Immunoprecipitation (IP) (109), Immunofluorescence (IF) (107), ELISA (52), Immunohistochemistry (IHC) (29), Enzyme Immunoassay (EIA) (11), Immunocytochemistry (ICC) (8), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (8), Functional Studies (Func) (7), Cytotoxicity Test (CyTox) (6), Blocking Antibody (Inhibition) (5), Immunoelectron Microscopy (IEM) (5), ELISA (Detection) (2), Radioimmunoassay (RIA) (2), Blocking Antibody (Inhibition) (1), Immunohistochemistry (Paraformaldehyde) (IHC (pfa)) (1), Neutralization (Neut) (1)
Conjugates FITC (91), Biotin (48), PE (38), APC (15), RPE (9), Cy5.5 (7), PE,Cy7 (7), Alexa Fluor 488 (6), Alexa Flour 488 (5), Alexa Fluor 350 (5), Alexa Fluor 555 (5), Alexa Fluor 647 (5), Cy3 (5), Cy5 (5), Cy7 (5), Gold (5), HRP (5), PE,Cy3 (5), PE,Cy5 (5), PE,Cy5.5 (5), RBITC (5), Cy5,PE (3), Cy5.5,PE (3), SPRD (3), Cy7,PE (2), Alexa Fluor 700 (1), Pacific Blue (1)
Epitopes pSer706 (1)